养阴通脑颗粒对麻醉犬脑血流量的影响  

Effects of yangyintongnao particle on cerebral blood flow in anaesthetized dog

作　　者：朱肖星[1] 梅其炳[1] 赵德化[1] 王跃民[2] 李民哲[2] 万海同[3] 

机构地区：[1]第四军医大学基础部药理学教研室,陕西西安710032 [2]第四军医大学基础部生理学教研室,陕西西安710032 [3]浙江中医学院

出　　处：《心脏杂志》2001年第2期98-100,共3页Chinese Heart Journal

基　　金：国家自然科学基金项目!( No.3 980 0 192 )

摘　　要：目的 :观察养阴通脑颗粒对麻醉犬脑血流量的影响。方法 :将 2 9只犬随机分为 5组 ,养阴通脑颗粒大剂量组(2 .0 g/kg) ;中剂量组 (1.0 g/kg) ;小剂量组 (0 .5 g/kg)及阳性药维脑路通组 (维脑路通 0 .0 2 5 g/kg) ,空白对照组给等量的生理盐水。结果 :养阴通脑颗粒 (0 .5 ,1.0 ,2 .0 g/kg)可增加麻醉犬的脑血流量 ,中剂量组在 30～ 90 m in时增加更明显 ,与维脑路通组比较 ,在 30 min时 ,大、中剂量组的脑血流量比维脑路通组明显 (P<0 .0 5 )。结论 :养阴通脑颗粒扩张脑血管的疗效比小剂量的维脑路通好。AIM:to study the effect of yangyintongnao particle on cerebral blood flow in anaesthetized dog. METHODS:29 dogs were randomly allocated to five groups. In control group physiological solution was administered with gastrogavage, In other four groups, a large dose of yangyintongnao particle(2 g/kg),a middle dose of yangyintongnao particle(1 g/kg),a small dose of yangyintongnao particle (0.5 g/kg) and weinaolutong pian were administered with gastrogavage respectively. Blood flow of artery carotis interna was detected by electricmagnetic flowmeter. RESUTS: Yangyintongnao particle can increase cerebral blood flow in campare to weinaolutongpian,a middle dose of yangyintongnao particle was remarkable in increasing,cerevral blood flow following administion 30,60 90 min, a middle dose and a large dose of yangyintongnao particle increase cerebral blood flow more than weinaolutong in 30 min. CONCLUSION: Yangyintongnao particle cause cerebral vasodilutation, it was obviously superior than a small dose of weinaolutongpian.

关 键 词：脑血流量 狗 麻醉 养阴通脑颗粒 中药 药理 

分 类 号：R285.5[医药卫生—中药学]