肉苁蓉多糖对衰老小鼠肺蛋白含量与抗氧化功能关系的影响  

Effects of cistanche desertica polysacchrides on the constitution of protein and anti-oxidative capacity of lune in aging mice

作　　者：孙云[1] 王德俊[1] 祝瑾[1] 张洪泉[1] 

机构地区：[1]扬州大学医学院抗炎免疫研究室,组织胚胎学教研室,扬州225001

出　　处：《中国药理学通报》2001年第1期101-103,共3页Chinese Pharmacological Bulletin

摘　　要：使用D 半乳糖造成小鼠实验性衰老模型 ,观察肉苁蓉多糖对实验性衰老小鼠肺胶原蛋白、弹性蛋白含量的影响 ,对肺组织和红细胞中超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH Px)及丙二醛 (MDA)含量的影响。结果　灌服肉苁蓉多糖的衰老小鼠的肺组织及红细胞中SOD、GSH Px活力不同程度提高 ,肺及血浆中丙二醛含量有所降低。同时肺胶原蛋白含量减少 ,弹性蛋白含量增多。AIM The relation between lung collagen,lung elastin and anti oxidative capacity was investigated in the experiment, and the aging model of mice was induced by D galactose. METHOD The aging mice treated with cistanche desertica polysacchrides (50,100 mg·kg -1 ·d -1 ) and determinate the modification of SOD、GSH Px、Vit E、MDA in blood and lung. RESULTS Cistanche desertica polysacchrides (CDP), which was isolated from Cistanche desertica cultivated in Xinjiang could enhance lung anti oxidative capacity and inhibit the modification of lung elatic constitution induced by D galactose. CONCLUSION Cistanche desertica polysacchrides have anti oxidative injury and anti aging effects on lung.

关 键 词：衰老 肺胶原蛋白 弹性蛋白 抗氧化功能 肉苁蓉多糖 抗衰老 

分 类 号：R977.9[医药卫生—药品]