山东地区MG易感性与HLA-DQB1基因多态性的相关性研究  

Study on the association HLA-DQB1 gene polymorphism and MG susceptibility in the Area of Shandong

作　　者：李效良[1] 杜克明[1] 宗传龙[1] 刘景升[1] 郭淼[1] 闫培全[2] 

机构地区：[1]泰山医学院生物学教研室,山东泰安271000 [2]山东医科大学附属医院内科,山东济南250012

出　　处：《泰山医学院学报》2001年第1期10-11,共2页Journal of Taishan Medical College

摘　　要：目的　探讨中国北方汉人HLA DQB1基因和重症肌无力的遗传易感性的相关性。方法　运用PCR SSP基因分型方法 ,对 5 3例MG患者及 5 0名健康对照组HLA DQB1基因进行分型 ,并对患者组和健康对照组的DQB1各等位基因频率进行比较。结果　DQB1 0 30 3的频率在患者组中明显升高 ,差异具有显著性意义。结论　DQB1 0 30 3参与北方汉人MG的易感性。Objective: To Analyze the susceptibility of HLA-DQB1 polymorphism to MG in the area of Northern China Methods: PCR-SSP was used to determine the HLA-DQB1 genotype of 53 MG patients and 50 healthy controls. And the frequencies of HLA-DQB1 alleles were compared between the MG patients and the healthy controls. Results: The frequency of DQB1*0303 was significantly increased in the MG patients (RR=2.26 P<005), compared to the controls. Conclusion: DQB1*0303 is susceptible to MG in Chinese Hans.

关 键 词：重症肌无力 遗传易感性 HLA-DQB1 基因多态性 PCR-SSP基因分型 

分 类 号：R394[医药卫生—医学遗传学]