血压不稳定引起的大鼠血管重构  

ARTERIES REMODELING INDUCED BY BLOOD PRESSURE LABILITY IN RATS

作　　者：陶霞[1] 张树辉[2] 缪朝玉[1] 楚正绪[1] 苏定冯[1] 

机构地区：[1]第二军医大学基础部药理学教研室,上海200433 [2]济南军区总医院病理科,济南250031

出　　处：《解剖学杂志》2001年第2期115-120,共6页Chinese Journal of Anatomy

基　　金：国家自然科学基金资助项目 :编号 396 70 831

摘　　要：目的 :观察去窦弓神经大鼠引起的血管重构。方法 :1 0周龄SD大鼠行去窦弓神经术或假手术 ,术后 4、8、1 6和 3 2周采用组织病理学和计算机图像分析技术对大鼠各级动脉连续切片进行观察和比较。结果 :与假手术组相比 ,去窦弓神经大鼠大动脉的重构主要以血管中层平滑肌细胞肥大和基质改变为主 ;中动脉的重构在血管中层平滑肌细胞肥大的同时可能有轻度的增生 ;小动脉主要以血管平滑肌细胞增生为主。结论Objective:To investigate the artery structural remodeling of rats in sinoaortic denervated rats.Methods:SD rats received either sinoaortic denervation or sham operation at the age of 10 weeks.The morphological changes of artery were examined by histopathological method and computer image analysis.Results:The structural remodeling of large aorta was characterized by medial VSMC hypertrophy and matrix changes.The medium arteries showed medial vascular smooth muscle hypertrophy may be accompanied by slight vascular smooth muscle hyperplasia.The small resistance arteries showed vascular smooth muscle hyperplasia.Conclusion:The present study provides detailed findings of vascular structural remodeling in sinoaortic denervated rats.

关 键 词：去窦弓神经 血管重构 血压不稳定 

分 类 号：R363[医药卫生—病理学]