甲型血友病患者输注“冷沉淀”后HBV和HCV相关指标的检测  

Detecting and Analysis to Hepatitis B&C Virus after Injecting Cryofibrinogen to Patients with Hemophilia

作　　者：余忠清[1] 胡丽华[1] 饶神宗[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院,武汉430022

出　　处：《中西医结合肝病杂志》2001年第2期80-81,共2页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:探讨甲型血友病患者大剂量反复输注“冷沉淀”后,HBV和HCV的感染情况,从而提出加强血液检测的新构想。方法:采用酶联免疫吸附法(ELISA)检测HBV和HCV,用速率散射比浊法测1g、C_3和C_4,用速率法测ALT。结果:20例患者血液中均检测出抗-HBs,而HBV-M的其他各项均为阴性,5例患者血液中检测出抗-HCV,其中1例伴ALT增高,3例伴Ig降低。结论:甲型血友病患者输注“冷沉淀”后易感HCV。治疗前接种乙肝疫苗可预防HBV感染。Objective: Investigate the infectious circumstance of hepatitis Virus in the patient with hemophilia after injecting a large amount of the cryofibrinogen for many time and present a new conception of detecting hepatitis virus through blood. Method: The enzyme-linked immunosorbent assay (ELISA) was used to explore hepatitis B virus (HBV) and hepatitis C virus (HCV) ,the rote nephelometry was used to explore Ig,C3 and C4. Result: 20 patients contain hepatitis B surface antibody (HBsAb). Hepatitis B surface antigen (HBsAg), hepatitis B core antibody IgM and IgG, hepatitis B e-antibody and hepatitis B e-antigen were all negative. Five patients contain HCV antibody and one of them was increased in ALT, three of them was decreased in Ig. Conclusion: Hemophilia after injecting cryofibrinogen is susceptive by HCV. But inoculating hepatitis B vaccine can prevente HBV infection before treatment.

关 键 词：甲型血友病 冷沉淀 乙型肝炎病毒 丙型肝炎病毒 

分 类 号：R554.1[医药卫生—血液循环系统疾病]