特发性眼睑口下颌痉挛综合征  

Ormandibular Dystonia Syndrome

作　　者：黄光[1] 汤晓芙[2] 戚晓昆[1] 

机构地区：[1]海军总医院神经内科 [2]北京协和医院神经内科

出　　处：《海军总医院学报》2001年第1期11-13,共3页Journal of Naval General Hospital of PLA

摘　　要：目的：观察特发性眼睑口下颌痉挛综合征的临床表现和Ａ－型肉毒毒素并联合口服抗痉挛药物的治疗效果。方法：对特发性眼睑口下颌痉挛综合征进行临床分析，使用Ａ－型肉毒毒素对痉挛肌肉进行多点注射（每点 ０．１～０．２ ｍｌ，２．５～５Ｕ），同时服用抗乙酰胆碱和苯二氮 卓类药物。结果：Ａ－型肉毒毒素对眼睑痉挛的治疗４～５天出现症状缓解，１个星期症状明显缓解，２个星期疗效达最高峰。有效率１００％，有效作用时间为１０～２４周，平均１１．７周。而抗乙酰胆碱和苯二氮 类药物对口下颌肌张力障碍的治疗效果比较明显，可以有效的缓解患者的磨牙咂嘴和舌不自主伸缩等症状。结论：Ａ－型肉毒毒素和抗乙酰胆碱及苯二氮 类药物联合应用是治疗特发性眼睑口下颌痉挛综合征的一种安全、有效、简便的方法。Objective: To study the clinical characteristic of Ormandibular Dystonia (OMD) Syndrome. To valuate the efficacy of CBTX-A (China botulinum toxin A) was made by Lanzhou Biological products institute in China, Artane and Clonazepam used for treatment OMD Syndrome. Methods: Thirty patients with OMD Syndrome were treated with CBTX-A local injections (2. 5-5 U for each injection) and Artance, Clonazepam tablets. Result: Spasm symptom slight relieved 4- 5 days after treatment and remarkable relieved one week after treatment. All patients experienced relief from spasm symptom. The relieved duration was 10 -24 weeks, (mean 11. 7 weeks). The local side effects were transient and mild, minor ptosis in 20%. Conclusion: The treatment of CBTX-A, Artane and Clonazepam was a safe, effective and simple means for OMD Syndrome.

关 键 词：特发性眼睑口下颌痉挛综合征 A-型肉毒毒素 肌张力障碍 治疗 

分 类 号：R746.905[医药卫生—神经病学与精神病学]