高原地区进展期胃癌患者红细胞免疫功能和T淋巴细胞亚群的研究  

T CELL SUBGROUP AND IMMUNOLOGIC FUNCTION OF ERYTHROCYTES IN PATIENTS WITH ADVANCED GASTRIC CANCER IN PLATEAU

作　　者：王见[1] 梁景星[1] 周晶萍[1] 王政[1] 

机构地区：[1]青海省人民医院肿瘤外科,810007

出　　处：《高原医学杂志》2001年第1期31-33,共3页Journal of High Altitude Medicine

摘　　要：目的 :研究高原地区进展期胃癌 (AGC)患者的红细胞免疫功能和淋巴细胞免疫功能 ;方法 :分别对我科住院手术治疗的 32例进展期胃癌患者作了红细胞C3b受体花环 (RBC -C3bRR)、红细胞免疫复合物花环 (RBC -ICR)及淋巴细胞亚群CD3、CD4、CD8、CD4/CD8的检测 ,并与 2 0例正常人结果进行比较 ;结果 :高原地区进展期胃癌患者RBC -C3bRR、CD3、CD4、CD8、CD4/CD8比值均低于正常人 (P <0 .0 1 ) ,RBC -ICR高于正常人 (P <0 .0 1 ) ;结论 :高原地区进展期胃癌患者红细胞免疫系统与淋巴细胞免疫系统均处于抑制状态 ,2个免疫系统的改变有着密切的联系 ,对高原地区进展期胃癌患者应给予免疫支持。To study changes of immunologic function of erythrocytes and lymphocytes in patients with advanced gastric cancer(AGC) at high altitude.Methods:32 cases with AGC and 20 healthy control were included in this study.The level of RBC C 3bRR,RBC-ICR,CD 3、CD 4、CD 8 and CD 4/CD 8 of lymphocytes were measured.Result:Level of RBC-C 3bRR,CD 3,CD 4,CD 8 and CD 4/CD 8 were less(P<0.01) in AGC group than those in control group but higher level of RBC-ICR.Conclusion:The immunologic system of erythrocytes and lymphocytes of patients with AGC are expressed under hypoxic environment,and there is a affective relationship in both.

关 键 词：高原 红细胞免疫 淋巴细胞亚群 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]