转人M受体亚型基因CHO细胞系在新药筛选中的应用  

Application of human muscarinic receptor subtype gene transfection CHO cell line in new drug screening

作　　者：邱瑜[1] 崔永耀[1] 陈红专[1] 

机构地区：[1]上海第二医科大学药理学教研室,上海200025

出　　处：《中国新药杂志》2001年第4期245-248,共4页Chinese Journal of New Drugs

基　　金：国家自然科学基金项目! (编号 30 0 70 86 0 )

摘　　要：综述了转人M受体亚型基因CHO细胞系在M受体亚型选择性新药筛选中的应用以及应用过程中应注意的问题 。The application of CHO cell line transfected with human muscarinic receptor subtype gene in new drug screening and the factors which may confound the results were reviewed.In addition,the screened out subtype selective musearinic agonists and antagonists were also briefly introduced. [

关 键 词：M受体 中国仓鼠卵巢细胞系 基因克隆 受体亚型 高通量药物筛选 M受体激动剂 M受体拮抗剂 

分 类 号：R965.1[医药卫生—药理学]