左氧氟沙星治疗细菌性角结膜炎的疗效  

Efficacy of levofloxacin eye drops in the treatment of bacterial conjunctivitis and keratitis

作　　者：陈樱[1] 喻长泰[1] 甘晓萍[1] 

机构地区：[1]武汉大学人民医院眼科,武汉430060

出　　处：《中国新药杂志》2001年第3期216-218,共3页Chinese Journal of New Drugs

摘　　要：目的 :验证 0 .3%盐酸左氧氟沙星滴眼液对细菌性角膜炎和结膜炎的疗效。方法 :试验组 31例用左氧氟沙星滴眼液 ,对照组 31例用氧氟沙星滴眼液 ,观察疗效和不良反应 ,测定 2药对结膜囊或角膜病灶分泌物细菌培养分离菌的敏感率和MIC。结果 :2药疗效无差异 ,但试验组疗程明显短于对照组 (P <0 .0 5 )。左氧氟沙星对分离菌的MIC极显著地低于氧氟沙星的MIC值 (P <0 .0 1)。结论 :0 .3%盐酸左氧氟沙星滴眼液具有抗菌谱广、活性高、使用安全等特点 ,是治疗细菌性角膜炎和细菌性结膜炎的良好药物。Objective:To observe the efficacy of levofloxacin eye drops in the treatment of bacterial conjunctivitis and keratitis.Methods:62 patients were divided to receive 0.3% levofloxacin eye drops( n =31) or 0.3% ofloxacin eye drops( n =31) and their efficacy and side effects were observed.The susceptibility and MIC of the 2 drugs to bacteria from cultured strain isolated from conjunctival capsule were also determined.Results:No significant difference in effective rate was observed between groups but significant difference existed between groups in treatment course with shorter course for levofloxacin group( P <0.05).And the MIC for levofloxacin group was significant lower than that of ofloxacin group( P <0.01).Conclusion:0.3% levofloxacin eye drops has a shorter course in treatment of bacterial conjunctivitis and keratitis in comparison with 0.3% ofloxacin eye drops. [

关 键 词：左氧氟沙星 氧氟沙星 细胞性角膜炎 细菌性结膜炎 治疗 

分 类 号：R772.210.5[医药卫生—眼科]