脑梗死急性期血小板超微结构的变化及意义  

Significance and ultrastructural change of platelet in patients with acute cerebral infarction

作　　者：聂志余[1] 郑悦[1] 张仲慧[1] 范蓉[1] 高政[1] 濮良忠[2] 曲淑闲[2] 王乃昌 

机构地区：[1]大连医科大学第二临床学院,116027 [2]大学第二临床学院大连医科大学中心实验室 [3]大连医科,116027

出　　处：《临床神经病学杂志》2001年第2期71-73,共3页Journal of Clinical Neurology

基　　金：辽宁省教委基金!资助课题编号 :970 72 2 10 72

摘　　要：目的　探讨脑梗死急性期血小板超微结构的变化及其意义。方法　采用透射电镜对 2 0例脑梗死急性期患者的血小板进行观察。结果　发病后 2 4小时内的血小板超微结构改变明显 ,表现为伪足增多 ,聚集融合成片状 ;α颗粒明显减少 ;线粒体也显著减少 ,残留者肿胀、空泡化 ;血小板膜多处破裂。血小板病变的严重程度与脑梗死病灶的大小相一致。发病后 2周血小板超微结构明显恢复 ,但 3例大面积脑梗死者未见恢复。结论　脑梗死急性期血小板超微结构发生明显改变 ,尤其是 α颗粒明显减少 ,可作为判断病情轻重及预后的一个客观指标。Objective To explore the significance and the ultrastructural changes of platelets in patients with acute cerebral infarction.Methods Changes of platelets in 20 patients with acute cerebral infarction were observed by transmission electron microscope.Results The ultrastructural changes of platelets within 24 hours after the onset were significant,including more pseudopodium,aggregation and fusion;there were remarkable fewer alpha granules and mitochondria,the remain of mitochondria swelled and more disruption of platelet membrance were found.The degree of platelet changes consisted with the severity and sizes of cerebral infarction.The ultrastructural change of platelets was obviously restored after 2 weeks,but no restoration was found in 3 patients with large area infarction.Conclusion Ultrastructural changes of platelets in acute period of cerebral infarction were remarkable,especially a lack of alpha granules,this might be regarded as an objective index in the judgment of severity and prognosis of cerebral infarction.

关 键 词：脑梗死 血小板 超微结构 

分 类 号：R743.33[医药卫生—神经病学与精神病学]