4-硒硫酸酯多糖对人肝癌细胞Bel/7402DNA RNA及蛋白质合成的影响  

INHIBITORY EFFECTS OF SE-CARRA ON DNA, RNA AND PROTEIN SYNTHESIS OF HUMAN HEPATOCARCINOMA CELLS BEL/7402 IN VITRO

作　　者：戴伟娟[1] 仲伟法[1] 索金良[2] 林志彬[2] 

机构地区：[1]济宁医学院药理学教研室 [2]北京医科大学

出　　处：《济宁医学院学报》2001年第1期18-19,共2页Journal of Jining Medical University

基　　金：CMB资助课题

摘　　要：目的　研究 4 -硒硫酸酯多糖体外给药对人肝癌细胞Bel 74 0 2DNA、RNA及蛋白质的抑制作用。方法　肿瘤细胞与不同浓度的药物培养 2 4h后 ,用同位素掺入实验 ,观察药物对肿瘤细胞DNA、RNA及蛋白质合成的影响。结果　 4 -硒硫酸酯多糖可抑制肿瘤细胞DNA、RNA及蛋白质合成。结论　 4 -硒硫酸酯多糖对瘤细胞生长的抑制作用 ,可能与抑制瘤细胞DNA。Objective To study inhibitory effects of Se-carra on DNA,RNA and protein synthesis of human hepatocarcinoma cells Bel/7402 in vitro Methods tumor cells were cultured for 24h with different drug densities Inhibitory effects of Se-carra on DNA,RNA and protein synthesis of tumor cells were observed by isotope incorporation experiment Results the results showed that Se-carra could inhibit the DNA,RNA and protein synthesis of the human hepatic carcinoma cell Lines Bel/7402,and its action of interfereing with DNA synthesis was the best Conclusion the results indicated that Se-carra has obviously depressing effects on DNA synthesis of liver cancer cells in vitro It is probable that these effects are related to antineoplastic activity

关 键 词：4-硒硫酸酯多糖 肿瘤细胞 DNA RNA 蛋白质 肝癌 

分 类 号：R735.7[医药卫生—肿瘤]