胃良、恶性病变中p16蛋白表达的研究  

To Study the Expression of p16 in Benign and Malignant Gastric Lesions

作　　者：范开席[1] 王绍平[1] 唐基栋[1] 王哲海[1] 

机构地区：[1]山东省肿瘤医院内二科,济南250117

出　　处：《肿瘤防治研究》2001年第2期98-99,共2页Cancer Research on Prevention and Treatment

摘　　要：目的　探讨 p1 6蛋白在胃良、恶性病变中的表达及其与胃癌的发生、发展的关系。方法应用免疫组化 LSAB方法 ,对 1 0例正常胃粘膜、35例良性病变和 65例胃癌中 p1 6的表达进行了检测。结果　p1 6蛋白在正常胃粘膜中的阳性率为 1 0 0 % ,在良性病变中的阳性率自 75%至 87.5%不等 ,在胃癌中的阳性率为 30 .8%。在高、中分化胃癌中 p1 6的阳性表达率高于低、未分化者 (P<0 .0 5) ,p1 6的阳性表达与 TNM分期密切相关。结论　 p1 6参与了胃癌的发生、发展过程 ,对预后的判断有意义。Objective To study the expression of p16 suppressor gene in benign and malignant gastric lesions and its correlation with occurrence and development of gastric cancer.Methods p16 was observed in 10 normal gastric tissue、35 benign lesions and 65 gastric cancer with LSAB immunohistochemical methods.Results The positive expression rate of p16 in the normal gastric tissue was 100%,the rate of benign lesions was 75%~87.5%,the rate of gastric cancer was 30.8%.The positive expression rate of p16 was higher in high and middle differentiation than low and small cell carcinoma (P<0.05) ,The positive expression of p16 was significantly correlated with TNM stage.Conclusion p16 may play some roles in the development of gastric cancer, the expression of p16 may assess the prognosis in gastric cancer.

关 键 词：胃癌 免疫组织化学 P16基因 P16蛋白 基因表达 

分 类 号：R735.2[医药卫生—肿瘤] R730.23[医药卫生—临床医学]