脑梗死患者血浆神经肽Y、降钙素基因相关肽、神经降压素、胃动素动态变化及其临床意义  

LEVEL CHANGES OF NEUROPEPTIDE Y,NEUROTENSIN,MOTILIN AND CALCITONIN GENE-RELATED PEPTIDE IN PLASMA OF PATIENTS WITH CEREBRAL INFARCTION AND THEIR CLINICAL SIGNIFICANCE

作　　者：李义召[1] 孙琳[2] 张东君[1] 刘爱芬[1] 刘建伟[3] 刘言训[4] 迟兆富[1] 韩丹春[1,4] 

机构地区：[1]山东大学齐鲁医院神经内科 [2]山东大学第二医院神经内科 [3]山东大学齐鲁医院同位素科 [4]山东大学公共卫生学院

出　　处：《山东医科大学学报》2001年第2期127-130,共4页Acta Academiae Medicinae Shandong

摘　　要：目的 :观察脑梗死 (CI)患者神经肽Y(NPY)、神经降压素 (NT)、胃动素 (MTL)、降钙素基因相关肽 (CGRP)浓度变化及其临床意义。方法 :选择CI6 2例 ,用放免法检测血浆NPY、NT、MTL与CGRP浓度。结果 :NPY、NT与MTL浓度显著高于对照组 (P <0 .0 0 0 1) ;于发病后 2 4h内显著升高 ,7d内达高峰 ,8～15d开始下降 ,15d后仍在较高水平。NPY浓度重型与大灶组显著高于轻型 (P <0 .0 5)与小灶组 (P <0 .0 1) ;发病积分≥ 6分组显著高于 <6分组 (P <0 .0 5) ;高血压组显著高于正常血压组 (P <0 .0 5)。NT与MTL浓度重型组显著高于中 (P <0 .0 5)、轻型组 (P <0 .0 1) ;高血糖组显著高于正常血糖组 (P <0 .0 1)。CGRP浓度显著低于对照组 (P <0 .0 0 0 1) ,发病 2 4h内即显著降低 ,2～ 7d进一步降低 ,8～ 15d开始升高 ,15d后逐渐升至正常水平。重型与大灶组显著高于轻型 (P <0 .0 0 0 1)、中型 (P <0 .0 1)与小灶组 (P <0 .0 1) ;伴发病积分≥ 6分组显著低于 <6分组 (P <0 .0 5)。结论 :CI患者NPY、NT、MTL、CGRP浓度变化以 7d内最显著 ,15d后逐渐恢复正常水平 ;四种浓度监测可作为判断CI患者病情严重程度、病灶大小及伴发病的实验室指标。Objective:To observe level changes of neuropeptide Y(NPY),neurotensin(NT),motilin(MTL) and calcitonin gene related peptide (CGRD) in plasma of patients with cerebral infarction and their clinical significance.Methods:The levels of above indicators were measured by radioimmunoassay in 62 cases (test group) with cerebral infarction and 28 subjects as the normal control.Results:In test group,the levels of DPY,NT,and MTL increased more than those in control group(P<0.0001).They started to increase significantly during the first day,and began to decrease seven days later.The level of CGRP had a contrary change with levels of NPY,NT,and MTL.There was a significant correlation between those indicators and some complicated diseases of cerebral infarction(P<0.05). Conclusion:The level changes of DPY,NT,MTL,and CGRP in patients with cerebral infarction were most significant in 7 days,and gradually recovered to normal levels 15 days later.They may be used as laboratory markers for severity of patient's condition,bulk of cerebral infarction and some complicated diseases.

关 键 词：脑梗死 降钙素基因相关肽 胃动素 神经降压素 神经肽Y 

分 类 号：R743.33[医药卫生—神经病学与精神病学]