动态观察脑出血患者血浆神经肽Y、神经降压素和胃动素的临床意义  

DYNAMICAL MEASUREMENT OF PLASMA NEUROPEPTIDE Y, NEUROTENSIN AND MOTILIN IN PATIENTS WITH CEREBRAL HEMORRHAGE AND ITS CLINICAL SIGNIFICANCE

作　　者：孙琳[1] 李义召[2] 刘爱芬[2] 张东君[2] 许军[2] 刘建伟[2] 刘艺鸣[2] 王晓云[2] 石峻峰[2] 

机构地区：[1]山东大学第二医院神经内科 [2]山东大学齐鲁医院神经内科

出　　处：《山东医科大学学报》2001年第2期131-133,共3页Acta Academiae Medicinae Shandong

摘　　要：目的 :动态观察脑出血患者血浆神经肽Y(NPY)、神经降压素 (NT)和胃动素 (MTL)的水平变化 ,探讨其临床意义。方法 :采用放射免疫方法测定了 4 6例脑出血患者及 2 8例健康成人血浆NPY、NT及MTL的含量。结果 :脑出血患者血浆NPY、NT及MTL水平均明显高于对照组 (P <0 .0 0 1,P <0 .0 1,P<0 .0 1)。发病 2 4h内即显著升高 ,NPY在 4～ 7d、NT和MTL在 1～ 3d达高峰 ,8～ 15d三者均开始下降 ,15d后仍在较高水平。重症患者NPY水平显著高于轻型和中型 ,中、重型患者NT水平显著高于轻型。大面积出血NPY、NT及MTL水平均高于小面积出血。伴发病积分≥ 6分者高于积分 <6分者。伴上消化道出血者显著高于不伴上消化道出血者。结论 :NPY、NT及MTL参与了脑出血的发生及病理生理过程。Objective:To observe the plasma Neuropeptide Y(NPY),Neurotensin(NT) and Motilin(MTL) concentration dynamically in patients with cerebral hemorrhage and its clinical significance.Methods:The levels of NPY,NT and MTL in plasma were measured by radio immunoassay in 46 cases of patients with cerebral hemorrhage and 28 healthy persons as the normal control.Results:Compared to the control group,the levels of NPY,NT and MTL in plasma in patients with cerebral hemorrhage increased significantly(P<0.001,P< 0.01 ,P<0.01).They began to increase in 24 hours,reached the peak during 1～3 or 4～7d,descended during 8～15d,and were even higher than those in control group at 15th day.The changes of NPY,NT and MTL were related with the diameter of hemorrhage site and some complicated diseases of cerebral hemorrhage.Conclusion:NPY,NT and MTL play an important role in pathophysiological and pathogenetic mechanisms of cerebral hemorrhage.

关 键 词：脑出血 神经降压素 胃动素 放射免疫测定 神经肽Y 

分 类 号：R743.34[医药卫生—神经病学与精神病学]