鼻咽癌患者β_2-MG和Fn水平测定及意义  

Detection of β_2-microglobulin and fibronection contents in patients with nasopharyngeal carcinoma and their clinical significance

作　　者：林钦[1] 付芬兰[1] 张国安[1] 

机构地区：[1]福州中国人民解放军第476医院五官科,350002

出　　处：《耳鼻咽喉（头颈外科）》2001年第2期105-106,共2页Chinese Arch Otolaryngology-Head Neck Surg

摘　　要：目的 :测定鼻咽癌患者血清β2 -微球蛋白 (β2 - MG)和纤维连接蛋白 (Fn)水平及意义。方法 :采用放射免疫检测技术和琼脂扩散法检测 6 0例鼻咽癌患者治疗前后血清β2 - MG和 Fn含量 ,并进行比较。结果 :鼻咽癌患者血清β2 - MG含量明显升高 ,但 Fn含量却明显降低 ,均有显著性差异 ;治疗后鼻咽癌患者β2 - MG含量明显下降 ,而 Fn含量显著升高。结论 :血清β2 - MG和 Fn含量的测定对鼻咽癌的诊断和预后评估有一定的意义。Objective:To study the clinical significance of β 2 microglobin(β 2 MG)and fibronection (Fn) contents in patients with nasopharyngeal carcinoma Methods:The contents of serum β 2 MG and Fn were detected by radioimmunoassay and agar diffusion methods in 60 patients with nasopharyngeal carcinoma before and after radiotherapy,also in 60 normal subjects as control group Results:The contents of serum β 2 MG and Fn were 2 99±1 11mg/L(β 2 MG)and 134 60±28 93mg/L(Fn) in 60 patients with nasopharyngeal carcinoma,2 16±0 50mg/L(β 2 MG)and 196 16±34 65mg/L(Fn)in 60 health subjects,respectively Those results showed that the content of β 2 MG in patients group was higher than that in control group (P<0 05),and the content of Fn in patients group was lower than that in control group(P<0 05) After radiotherapy of patients group,the content of β 2 MG were lower(2 16±0 55mg/L)than that before radiotherapy(P<0 05) Conversely,the content of Fn was higher(180 53±34 66mg/L)than after radiotherapy(P<0 05) Conclusions:The detection of serum β 2 MG and Fn have clinical significance on the evaluation prognosis of patients with nasopharyngeal carcinoma

关 键 词：鼻咽癌 纤维蛋白 球蛋白类 

分 类 号：R739.63[医药卫生—肿瘤]