肝癌病人血清纤维连接蛋白和透明质酸意义的初步探讨  

Study of Serum Fibronectin and Hyaluronic Acid in Patient with Hepatocellular Carcinoma

作　　者：裴海平[1] 吕新生[1] 张成裕[1] 刘鹏熙[1] 

机构地区：[1]中南大学湘雅医院普外科,湖南长沙410008

出　　处：《中国医师杂志》2001年第4期262-263,共2页Journal of Chinese Physician

摘　　要：目的　探讨纤维连接蛋白 (Fn) ,透明质酸 (HA)与肝癌的关系及其临床应用的价值。方法　应用酶标仪比浊法及放免技术对 50例肝癌病人血清Fn和HA测定 ,并以肝良性病变和正常人作对照。结果　肝癌病人血清Fn含量明显低于肝良性病变组及正常对照组 (P <0 0 0 1) ,而肝癌病人血清HA含量均高于肝良性病变组及正常对照组 (P <0 0 0 1)。以Fn =2 2 0mg/L ,HA =4 0 μg/L为界诊断肝癌敏感性分别为 90 0 %、86 0 %。结论　肝癌发生发展与细胞外间质有着密切关系。Objective To study the relationship between serum fibronectin(Fn) and hyaluronic acid(HA) in patients with hepatocellular carcinoma(HCC) and their clinical value.Methods The serum Fn and HA levels in 50 cases of HCC 14 cases of benign hepatic disease and 100 healthy persons were determined by enzyme-labelled turbidimetry and radioimmuoassay.Results The serum Fn content (125.85±29.47)mg/L of the patients with HCC was significantly lower than those of both the benign hepatic disease(210.14±18.36)mg/L and healthy controls (219.96±26.26)mg/L,P<0.001.However,the HA level (239.29±68.06)mg/L of the patients with HCC was obviously higher than that in both the benign hepatic patients (45.12±14.37)mg/L and healthy controls (41.06±8.45)μg/L,P<0.001.Fn=220mg/L and HA=40μg/L were used as cut off marks,the sensitivities of diagnosis of hepatocellular cancimoma were 90.0% for Fn as well as 86.0% for HA,respectively.Conclusions It suggests that etiology of HCC may be ralated to extracellular matrix(ECM),and the detection of Fn and HA in serum may be helpful to the diagnosis of HCC.

关 键 词：肝细胞癌 纤维连接蛋白 透明质酸 诊断 

分 类 号：R735.7[医药卫生—肿瘤]