胃癌高发现场干预实验人群中巯基代谢产物的检测  

Detection of SH Chemicals Among Population at Gastric Cancer

作　　者：关鹏[1] 周宝森[1] 张群弟[1] 袁媛[1] 

机构地区：[1]中国医科大学流行病学教研室,辽宁沈阳110001

出　　处：《肿瘤防治杂志》2001年第1期3-40,共38页China Journal of Cancer Prevention and Treatment

摘　　要：目的 :选用巯基代谢产物做为服用大蒜素的客观指标 ,来判定胃癌高发现场综合干预实验中受试对象服药的依从情况。方法 :应用磷钨酸还原法测定受试对象尿液中巯基含量。结果 :服用大蒜素组尿液巯基含量为 10 4 1U ,明显高于未服用大蒜素组的 2 94U ,P <0 0 5。结论 :对大规模人群干预实验中受试对象的生物样品中药物的代谢产物进行测定具有可行性 。Objective To evaluate the compliance situation in the intervention trial among the population at gastric cancer risk.Methods Detect the SH chemicals in the urine of people who have had garlic extracts.Results The SH chemicals in the urine of the garlic extracts treatment group is 10 41 U/100 ml,the other group is 2 94 U/100 ml.It is statistically significant that the mean value of SH chemicals was higher in the garlic extracts treatment group.Conclusions Detecting the metabolites in the biosamples has its feasibility in the large population based intervention trial,it is a good way for quality control.

关 键 词：流行病学 尿流 巯基 测定 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]