大肠肿瘤血管内皮生长因子的表达及其作用机制探讨  

The Expression of VEGF in Colorectal Neoplasm and Discussion of Its Active Mechanism

作　　者：杨明智[1] 陈汝福[1] 陈积圣[1] 毛伟征[2] 张敬智[2] 

机构地区：[1]中山医科大学孙逸仙纪念医院肝胆外科,广东广州510120 [2]青岛大学医学院附属医院普外科,山东青岛266003

出　　处：《肿瘤防治杂志》2001年第1期38-40,共3页China Journal of Cancer Prevention and Treatment

摘　　要：目的 :通过检测血管内皮生因子 (VEGF)的表达来明确它与大肠肿瘤临床病理因素的关系。方法 :应用免疫组织化学方法 (SABC法 ) ,采用VEGF多克隆抗体测定 55例病理证实的大肠癌标本及 17例大肠腺瘤标本中VEGF的表达。结果 :大肠癌VEGF的阳性例数为 36,表达率 ( 65% )高于大肠腺瘤 ,差别显著 (P <0 .0 5) ;发生淋巴结转移大肠癌VEGF的表达率高于未发生转移的大肠癌 ,差别显著 (P<0 .0 5) ,未发生淋巴结转移大肠癌VEGF的表达率高于大肠腺瘤 ,差别显著 (P <0 .0 5) ,结论Objective To determine the expression of VEGF in colorectal neoplasm and its clinical significance.Methods The expression of VEGF in 55 patients with colorectal carcinoma and 17 patients with adenomas were investigated using immunohistochemical staining.Results The positive rates of VEGF colorectal cancer were significantly higher than that of adenomas ( P <0.05);VEGF in colorectal cancer were significantly correlated with lymphnode metastasis ( P <0.05);VEGF expression was significantly increased from adenomas to colorectal cancer without lymph node metastasis ( P <0.05).Conclusions Over expression of VEGF existed in colorectal neoplasm was likely to show carcinomatous change and an increased character of metastasis.

关 键 词：大肠肿瘤 内皮生长因子 血管 免疫组织化学 

分 类 号：R735.34[医药卫生—肿瘤]