互隔交链孢霉毒素AME和AOH合成物的诱变性  

Mutagenicity of synthetical mycotoxin of AME and AOH of AI-ternaria alternata

作　　者：苏堤[1] 李玉华[1] 阮丽荣[1] 徐友梅[1] 

机构地区：[1]河南医科大学微生物学教研室

出　　处：《河南医科大学学报》1991年第3期239-240,共2页Journal of Henan Medical University

摘　　要：对互隔交链孢霉毒素——交链孢酚单甲醚(Alternariol monomethyl ether,AME)和交链孢酚(Alternariol.AOH)的合成物进行了细菌回复突变试验.检测其诱变性。结果表明:AME和AOH提取物和合成物(不加S_9)对鼠伤寒沙门氏菌TA102菌株和大肠菌ND-160菌株.均显示致突变效应.而后者对AME和AOH更为敏感。用相同剂量.AOH对大肠杆菌ND—160菌株诱变比值(MR)比AME高2～7倍,表明AOH的诱变性更强。合成物与提取物相比,合成物的诱变作用较强。Mutagenicity of synthetical and extractive AME (alternariol monomethyl ether) and AOH (al-ternariol)of Alternaria alternata was studied with reverse mutation test of bacteria. The results showedthat synthetical and extractive AME and AOH had mutagenic effects on Salmonella typhimurium TA102 and E. Coli ND--160 strains(without S_9),and the latter was more sensitive. With the same doses,the rate of mutation of E. coli ND--160 with AOH was 2--7 times higher than that with AME. Themutagenic effect of the synthetic compound was stronger than that of the extract.

关 键 词：链格孢属 霉菌毒性 AME AOH 

分 类 号：R730.231.3[医药卫生—肿瘤]