二甲基肼诱发小鼠大肠肿瘤核仁形成区观察  

Nucleolar Organizer Regions of 1,2—Dimethylhydrazine Induced Cancer of the Large Intestines in Mice

作　　者：王永军[1] 祝庆蕃[1] 薛乐勋[2] 

机构地区：[1]河南医科大学病理学教研室 [2]河南医科大学医学实验中心

出　　处：《河南肿瘤学杂志》1991年第4期5-6,共2页Henan Journal of Oncology

摘　　要：应用银染技术研究二甲基肼诱发小鼠大肠肿瘤及其背景粘膜隐窝上皮细胞的核仁形成区。发现癌细胞与异型隐窝细胞的Ag—NORs数目无明显差异,正常隐窝与增生性隐窝细胞的Ag—NORs数目无明显差异。但与异形隐窝细胞有显著差异。提示Ag—NORs可为大肠癌的癌前病变提供客观辅助诊断指标。A survey of nucleolar organizer regions(NORs) in nuclei of 1,2—dimethylhydrazine(DNH)—induced Carcinoma and crypt epithelia of the large intestines in mice was made, using a silver staining technique. The results showed that the nuclei of carcinoma and dysplastic crypt epithelia of the large intestines contained similar number of Ag—NORs; there was significant difference in the number of Ag—NORs between normal and dysplastic crypt cells, but no difference between normal and hyperplastic crypt cells. These findings suggest that Ag—NORs may be an objective marker for detecting precancerous lesions of the large intestines.

关 键 词：二甲基肼 大肠肿瘤 核仁区形成 

分 类 号：R735.34[医药卫生—肿瘤]