三唑醇类化合物的合成及抗真菌活性  

Synthesis and Antifungal Activity of Novel Triazole Alcohols

作　　者：甘亚[1] 吕丁[1] 刘剑[1] 田敏[1] 

机构地区：[1]四川抗菌素工业研究所,四川成都610051

出　　处：《中国药物化学杂志》2001年第2期85-88,共4页Chinese Journal of Medicinal Chemistry

基　　金：国家青年新药基金项目! (No.96 90 1 0 5 1 2 8)

摘　　要：本文根据三唑醇类抗真菌化合物构效关系研究的结果提示 ,以氟康唑为先导物 ,设计合成了 1 1个未见文献报道的新三唑醇类化合物 ,经体外抗真菌活性筛选 ,以氟康唑为参照物 。Based on the result of QSAR which was studied among a series of triazole antifungal agents,11 new compounds were designed and synthesized,and they were identified with MS,IR, 1H NMR.Screened in vitro and compared to control compound fluconazole,four of those showed good antifungal activity.

关 键 词：三唑醇 合成 抗真菌活性 

分 类 号：R914[医药卫生—药物化学]