核增殖抗原表达基因Ki67与人肺癌临床病理生理特征及其预后的关系  

Expression of Ki67 Gene in Primary Lung Cancer:Relation with the Clinicopathological Parameters and Prognosis of Patients

作　　者：王允[1] 周清华[1] 陈桂枝[1] 张尚福 成娘 张宏伟[1] 伍伫[1] 刘伦旭[1] 车国卫[1] 刘朝阳[3] 

机构地区：[1]华西医科大学附属第一医院胸心外科,,成都610041 [2]病理科 [3]成都市第二人民医院胸心外科

出　　处：《中国胸心血管外科临床杂志》2001年第2期103-106,共4页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：国家自然科学基金! (3 9870 2 99);国家教委博士点基金!(9849)&&

摘　　要：目的　研究细胞增殖状态与肺癌临床病理生理特征和预后的关系 ,探讨 Ki6 7对临床诊断和预后判断的价值。　方法　应用免疫组织化学法检测 16 6例肺癌组织标本和 37例肺良性病变组织中 Ki6 7的表达水平。　结果　(1)肺癌组织中 Ki6 7指数显著高于肺良性病变组织 (P<0 .0 1) ,而癌旁组织与良性病变组织相比差别无显著性意义 ;(2 )肺癌组织中 Ki6 7表达水平增强与肺癌组织学类型、细胞分化程度有关 (P<0 .0 5 ) ,而与患者 PTNM分期、淋巴结转移程度、吸烟与否以及患者的性别、年龄无明显关系 ;(3) Ki6 7高表达组肺癌患者的术后生存时间显著低于低表达组 (P<0 .0 1) ,按 PTNM分期分层后这种差别仍然存在 (P<0 .0 5 )。　结论　 Ki6 7能较好地反映肺癌细胞的增殖状态 。Objective To investigate the relationship of Ki67 with the clinicopathological parameters and prognosis of primary lung cancer patient. Methods The expression of Ki67 gene were detected in 166 lung cancer samples and 37 benign lesion tissues of lung as control by immunohistochemistry. Results (1) The Ki67 index was significantly higher in lung cancer tissues than in benign lesion tissues(P<0.01), otherwise, no notable difference was found between normal tissues adjacent to cancer and controls(P>0.05); (2) The expression level of Ki67 gene was closely related to histological classification and cancer cell differentiation(P<0.05), and there was no significant relationship between Ki67 expression and PTNM stages, lymph node involvement, smoking habit, sexuality and age of lung cancer patients (P>0.05); (3) The postoperative survival time of patients in high Ki67 expression group was significantly shorter than those in low expression group (P<0.01), and this reverse association between Ki67 index and survival time is independent to PTNM stages of patients(P<0.05). Conclusion Ki67 is a favorable marker to proliferation of lung cancer cells, and can provide useful information for diagnosis and prognosis of lung cancer patients.

关 键 词：KI67基因 细胞增生 免疫组织化学 肺癌 预后 病理生理学 

分 类 号：R734.2[医药卫生—肿瘤] Q344.13[医药卫生—临床医学]