周围型肺癌SCT增强扫描与血管超微结构和密度的相关性  

Correlation of Degree Spiral CT Enhancement and Ultrastructure and Density of Microvessels in Peripheral Lung Cancer

作　　者：周晓琳 曾纪珍[2] 杨迎[2] 周建华[3] 张常安 

机构地区：[1]湖南省长沙市一医院CT室,湖南长沙410005 [2]湖南医科大学湘雅医院放射学教研室 [3]湖南医科大学病理教研室 [4]湖南医科大学电镜室

出　　处：《实用放射学杂志》2001年第3期166-168,共3页Journal of Practical Radiology

摘　　要：目的 :探讨螺旋CT增强扫描与周围型肺癌微血管超微结构和密度相关性。方法 :对 31例手术、病理证实的周围型肺癌 ,术前进行螺旋CT增强扫描 ;电镜观察离体肺癌血管超微结构 ,并对肺癌标本用SP法进行Ⅷ因子免疫组化染色。结果 :①肺癌微血管内皮细胞间形成缺口 ,基底膜断裂或缺乏 ,癌细胞间隙较大。②周围型肺癌螺旋CT扫描增强程度与微血管密度 (MVD)呈正相关 (r =0 .92 6 ,Ρ <0 .0 1)。结论 :周围型肺癌螺旋CT增强扫描的增强程度 ,反映了肺癌血管超微结构异常和富血管度。Objective:To study correlation of degree spiral CT enhancement and ultrastruction and density microvessel in peripheral lung cancer.Methods:31 cases of peripheral lung cancer comfirmed by operatien and pthology were examined with spiral computed tomography of enhancement with iodiated contrast meaterial before operaton.Ultrastructure and density microvessels were observed by transmission electron microscope and immunohistochemical method by factor Ⅷ on the specimens of the resected tumors.Results:①A increase in microvessel permeability of lung cancer resulted from gap between endotheliums of microvessel,lack of basement membrane of cracking,large cancer cell space.②The degree of spiral CT enhancement was correlated with microvessel density in peripheral lung cancer(r=0.926,Ρ<0.01).Conclusion:The dagree of spial CT enhancement demonstrates abnormal ultrastructure and density of microvessel in periphral Lung cancer. [

关 键 词：X线计算机断层摄影术 周围型肺癌 超微结构 MVD SCT增强扫描 密度 

分 类 号：R734.2[医药卫生—肿瘤]