增殖细胞核抗原在血管瘤组织中的表达及临床意义  

The expression of proliferating cell nuclear antigen in hernangioma and its significance

作　　者：程立新[1] 汤少明[2] 罗少军[2] 郝新光[2] 

机构地区：[1]汕头大学医学院第一附属医院整形科 [2]广东医学院整形外科研究所

出　　处：《中华医学美容杂志》2001年第2期75-76,共2页

摘　　要：目的　探讨PCNA在血管瘤中的表达及临床意义。方法　根据Mulliken分类法将 3 0例血管瘤标本分为 3组 :增殖期 (≤ 1岁 ) 11例 ,退化期 (≤ 5岁 ) 9例 ,退化完成期 (≤ 12岁 ) 10例 ,用免疫组化链霉菌抗生物素蛋白 -过氧化物酶连接法检测 3组不同时期血管瘤标本中PCNA表达。结果　PCNA在增殖期阳性细胞表达指数最高为 ( 62 .5 0± 9.49) % ,退化期次之为 ( 3 7.5 6± 10 .5 7) % ,退化完成期最低 ( 12 .2 0± 6.0 9) % ;三者相互间有显著性差异。结论　根据以上结果 ,我们认为PCNA在不同时期血管瘤中表达不同 ,可作为划分不同时期血管瘤的一种标志物。Objective In order to study the expression of PCNA in hemangioma and its clinical significance.Methods We devided thirty cases of hemangioma into three groups based on Mulliken classification: eleven cases of proliferating stage(≤one year);nine cases of revoluting stage(≤ five year); ten cases of revolution completed stage(≤ twelve year). Then we investigated the expression of PCNA in hemangioma samples of these three different stage groups by immunohistochemical streptavidin peroxidase conjugated method.Results The positive cell expression index of PCNA was highest in proliferating stage (62.50±9.49 %), took second place in revoluting stage (37.56±10.57 %),was lowest in revolution completed stage(12.20±6.09 %).The differences among these three groups were significant.Conclusion We concluded from above that PCNA expressed differently in three different stages of hemangioma, and it can be used as an objective basis for deviding different stages of hemangioma.

关 键 词：血管瘤 增殖性细胞核抗原 PCNA 重度组织化学 SP法 

分 类 号：R732.2[医药卫生—肿瘤]