尿α_1-MG检测对顺铂联合化疗后肾毒性的临床意义  

Clinical significance of measuring α_1－microglobulin from urine in the renal of combinging cisplatin－based chemotherapy

作　　者：郑鸿[1] 陈声波[1] 

机构地区：[1]江西医学院一附院肿瘤科,南昌330006

出　　处：《江西医药》2001年第2期84-85,共2页Jiangxi Medical Journal

摘　　要：目的 探讨尿α_1－MG是否反映DDP联合化疗后肾毒性的灵敏又特异的指标；了解不同剂量DDP联合化疗后肾毒性恢复正常所需要的时间。 方法 用放射免疫法测尿α_1－MG／尿Cr的比值在不同剂量DDP为主化疗后肾毒性的临床意义，同时测定血肌酐、尿素氮。 结果 健康人与肿瘤病人尿α_1－MG值无统计学差异（P＞0．05）；不同剂量DDP组化疗后尿α_1－MG／尿Cr比值增多高于化疗前，化疗后第3d最高，剂量越大比值越高，恢复正常所需时间越长，大剂量组约7～10d恢复至化疗前水平。血BUN、肌酐化疗前后无统计学差异。 结论 尿α_1－MG是测定DDP联合化疗后肾毒性大剂量约7～10d恢复正常。Objectiye： To study whether the urinary α_1－microglobulin（α_1－MG）was a sensitive and specific indictor for the renal damage of combining cisplatin－based chemotherapy and to investigate how long time the renal damage to recover nomal level after chemotherapy with different dose cisplation． Methods The urinary α_1－MG was assayed before and after chemotherapy in the different dose cisplatin groups and also the blood Cr、BUN were assayed． Results urinary α_1l－MG had no statistic difference between the tumor and the healthy groups（P＞0．05）：The value of the urinary α_1－MG／Cr after chemotherapy was higher than that of before chemotherapy in all the different dose DDP groups，and raised the highest in the third days after therapy． It needed about7－10 days to recover in high dose group． While the plasmaBUN、Cr had no statistic difference between before and after DDP chemotherapy（P＞0．05）． Conclusion ⑴urinary α_1－MG is a sensitive and reliagble indicator for the renal damage of combining cisplatin－based chemotherapy⑵There is 7－10 days for nephrotoxicity recoveering normal lever in high－dose groups．

关 键 词：肿瘤 化疗 肾毒性 顺铂 尿 Α1-MG 

分 类 号：R730.53[医药卫生—肿瘤] R692[医药卫生—临床医学]