联合化疗加粒细胞集落刺激因子动员外周造血干细胞的作用  

Effect of peripheral blood stem cells mobilization by high-dose combination chemotherapy plus low-dose G-CSF after inductive chemotherapy

作　　者：罗以[1] 何执鼎[1] 吴扬 杜娟[1] 张萍[1] 孙忠义 周芳[1] 

机构地区：[1]湖南省肿瘤医院内科,湖南长沙410006

出　　处：《中国癌症杂志》2001年第2期151-152,共2页China Oncology

摘　　要：目的 :研究大剂量联合化疗 (HDCT)加粒细胞集落刺激因子 (G CSF)对外周血造血干细胞的动员作用。方法 :8例非霍奇金淋巴瘤 (NHL)多周期诱导化疗达完全缓解后 ,采用大剂量联合化疗 ,联合应用小剂量G CSF进行外周造血干细胞的动员。结果 :动员后外周血WBC及MNC总数明显增加 ,与动员前比较 ,差异有显著性。冷冻前后 ,MNC计数、GFU G集落总数无明显差异。预处理后 ,病人中性粒细胞、血小板恢复时间分别平均为 (10 5± 4)天及 (11 5± 6 )天。结论 :大剂量联合化疗加小剂量G CSF联合动员方案是安全有效的 ,值得推广。Purpose:To explore the effect of high-dose combination chemotherapy and low dose G-CSF on peripheral blood stem cell (PBSC) mobilization. Methods:After inductive chemotherapy, the peripheral blood stem cells in the eight patients of non-Hodgkin's lymphoma (NHL) with complete remission were mobilized by high-dose combination chemotherapy and low-dose G-CSF. Results:The WBC and MNC counts were increased significantly in post-mobilization. The MNC and GFU-G counts were unchanged regardless of pre-freezed or post-freezed conditions. After the patients were pre-treated, the recovery time of neutrophil and platelet were (10.5±4) days and (11.5±6) days.Conclusions:The mobilizing regimen of high-dose combination chemotherapy and low-dose G-CSF is effective and safe, and can be clinically used.

关 键 词：造血祖细胞 大剂量化疗 造血细胞生长因子 HDCT G-CSF 非霍奇金淋巴瘤 

分 类 号：R733.1[医药卫生—肿瘤] R730.53[医药卫生—临床医学]