72例多发性骨髓瘤单克隆蛋白分析  

Analysis of monoclonal protein in 72 cases of multiple myeloma

作　　者：杨俊杰[1] 张广森[1] 陈新瑞[2] 裴敏飞[1] 韩照平[1] 申建凯[1] 

机构地区：[1]中南大学湘雅二医院血液科,长沙410011 [2]中南大学湘雅二医院检验科,长沙410011

出　　处：《湖南医科大学学报》2001年第2期152-154,共3页Bulletin of Hunan Medical University

基　　金：国家自然科学基金部分资助!( 3 95 70 3 2 4)

摘　　要：用速率散射比浊法测定 72例多发性骨髓瘤 (MM)血清与尿中单克隆蛋白 (M蛋白 )。结果显示 ,与IgG型 ,IgA型对应的免疫球蛋白 (Ig)均显著增高 ,不对应的Ig均明显降低。无论κ或λIgG ,IgA型 ,其对应的血清轻链显著增高 ,不对应的血清轻链显著降低。无论LC κ或是LC λ型 ,对应的血轻链在正常范围 ,不对应的血轻链低于正常 ,而尿中对应的轻链显著增高。在IgG ,IgA ,LC三型中 ,血清与尿中轻链κ/λ均显著异常。提示 ,血清中κ轻链 >2 0g·L 1或 <5g·L 1,λ轻链 >10g·L 1或 <2g·L 1,血、尿中κ/λ >5或 <0 .75时 ,任一项指标对MM的诊断均具有重要价值。Serum and urinary monoclonal proteins (M protein) were measured in 72 cases of multiple myeloma (MM) using rate nephelometry. In IgG and IgA types of MM, the level of immunoglobulin (Ig) corresponding to the malignant isotype was significantly higher and that of Ig uncorresponding to the malignant isotype lower than the normal level. The light chain corresponding to the malignant isotype in serum was increased and the light chain uncorresponding to that in serum was decreased either kappa IgG, IgA types or lambda IgG, IgA types. Either kappa LC or lambda LC type of MM, the serum light chain corresponding to the malignant isotype was in the normal range and uncorresponding to that was decreased,and the corresponding light chain in urine was significantly elevated. Kappa/lambda ratio in serum and urine was all significantly abnormal in IgG, IgA, and LC types of MM.Our data suggest that any quota among kappa light chain>20?g.L 1 or<5?g·L 1 ,lambda light chain>10?g·L 1 or<2?g·L 1 in serum and kappa/lambda ratio>5 or<0.75 in serum and urine has an important value for diagnosing MM.

关 键 词：多发性骨髓瘤 单克隆蛋白 实验室诊断 回顾性研究 

分 类 号：R733.3[医药卫生—肿瘤]