兔眼植入氟-肝素表面修饰人工晶状体表面细胞计算机图像分析  

Computerized image analysis of cells on the surface of F-heparin surface modified intraocular lens after implantation in rabbits’eyes

作　　者：孙慧敏[1] 郭红玉[1] 徐延山[1] 袁佳琴[1] 顾汉卿[2] 陆茉珠[2] 

机构地区：[1]天津医科大学眼科中心,300070 [2]天津市泌尿外科研究所

出　　处：《眼科研究》2001年第2期120-122,共3页Chinese Ophthalmic Research

摘　　要：目的 探讨作者研制的氟－肝素表面修饰人工晶状体（Ｆ－ＨＳＭ ＩＯＬ）的生物相容性。方法 Ｆ－ＨＳＭ ＩＯＬ及ＰＭＭＡ人工晶状体（ＰＭＭＡ ＩＯＬ）各３２枚植入兔眼。利用计算机图像分析仪对人工晶状体表面细胞构成、各种细胞平均面积、细胞总面积覆盖率和细胞密度进行分析。结果 Ｆ－ＨＳＭ ＩＯＬ及ＰＭＭＡ ＩＯＬ表面细胞均以巨噬细胞为主。 Ｆ－ＨＳＭ１０Ｌ组各种细胞平均面积小于ＰＭＭＡ ＩＯＬ组，细胞总面积覆盖率和细胞密度均低于ＰＭＭＡ ＩＯＬ，两组有显著差别，Ｐ＜０． ０５ 。结论 氟一肝素表面修饰人工晶状体有较好的生物相容性。ObjectiveTo study the biocompatibility of the F-heparin surface modified intraocular lens(F-HSM IOL) designed by the authors.Methods32 F-HSM IOL and 32 PMMA IOL were implanted into the rabbits’ eyes.Constitution and mean area of various kinds of cells on the surfaces of intraocular lens,percentage of total area of covering cells,as well as density of cells were studied using computerized image analyser.ResultsThere were chiefly macrophages on the surface of both F- HSM IOL and PMMA IOL.The mean area of cells,the total area of covering cells and desity of cells on the F-HSM IOL were significantly smaller (P.<0.05) than those on the PMMA IOL. Conclusion The F-HSM IOL seems to possess better biocompatibility.

关 键 词：氟离子 肝素 人工晶状体 细胞反应 计算机图像分析 白内障 生物相容性 HSM-IOL PMMA-IOL 

分 类 号：R779.66[医药卫生—眼科]