淋巴滞留性脑水肿大鼠神经元形态改变的观察  

Study on the neuronal morphology of lymphostatic cerebroedema in rats

作　　者：陈玉社[1] 夏作理[1] 杨明峰[1] 公丕欣[1] 韩丹春[2] 

机构地区：[1]泰山医学院附属医院微循环研究所,山东泰安271000 [2]山东医科大学附属医院神经内科,山东济南250012

出　　处：《中国病理生理杂志》2001年第4期356-358,T004,共4页Chinese Journal of Pathophysiology

基　　金：山东省卫生厅科研基金!资助项目 (No .96 115 )

摘　　要：目的 :探讨淋巴滞留性脑水肿发病过程中神经元的病理学改变。方法 :采用结扎颈部浅、深淋巴管并摘除相应淋巴结的方法 ,复制Wistar大鼠的淋巴滞留性脑水肿模型 ,分别于术后不同时间取脑组织 ,进行光镜及电镜观察。结果 :术后 2d出现脑组织水肿 ,顶叶大脑皮质及海马CA1区可见到神经元的凋亡及坏死两种形态学改变 ,以术后 5 - 7d最显著。结论 :脑淋巴引流阻断可导致淋巴滞留性脑水肿 ,神经元的凋亡及坏死是其主要病理变化。AIM: To investigate the pathological feature of neuron in the process of lymphostatic cerebro dema.METHODS: The model of lyphostatic cerebro edema was established by occluding and removing both the shallow and deep cervical lymph nodes in rats. The tissues of their brains were studied at different times after the operation, under light-microscope (HE stain and TUNEL stain) and electron-microscope.RESULTS: Cerebroedema appeared 2 days after the blockage of cervical lymphatic. Apoptosis and necrosis of neuron were observed in cerebral cortical of parietal lobus and hippocampal CA1 sector mainly. The alterations above were most noticeable at fifths day after the blockage. CONCLUSION: The blockage of the drainage of the cerebral lymphatic can lead to lymphastatic cerebroedema. Neuronal apoptosis and necrosis was the main pathological feature in the brain.

关 键 词：大鼠 淋巴滞留性脑水肿 神经元 病理学 

分 类 号：R742.7[医药卫生—神经病学与精神病学]