生物蜂王浆抑制腹水型肝癌细胞H_(22)生长的实验研究  

Experimental study of the inhibitory effects of biotic royal jelly on the growth of ascitic hepatoma cell H_( 22) in mice

作　　者：王勇姿[1] 凌昌全[1] 黄雪强[1] 潘品荣 

机构地区：[1]第二军医大学长海医院中医科,上海200433 [2]浙江省嘉兴市蜂宝研究所

出　　处：《第二军医大学学报》2001年第4期357-359,共3页Academic Journal of Second Military Medical University

基　　金：上海市科委科技发展基金!资助项目(98XD14 0 2 0 )

摘　　要：目的 :观察生物蜂王浆对腹水型肝癌细胞 H2 2 体内生长的抑制作用。方法 :以不同的生物蜂王浆即 :经扶正抗癌 1号方、以毒攻毒 2号方、清热解毒 3号方喂养的蜜蜂所分泌的蜂王浆分别灌喂荷 H2 2 肿瘤小鼠后 ,观察其体内抗肿瘤效果 ,并以普通蜂王浆和生理盐水灌喂为对照。 结果 :在所有生物蜂王浆灌喂组中 ,1号生物蜂王浆有明显抑制肿瘤生长和延长生存期的作用 ;并能显著增加小鼠外周血白细胞数 ,升高血 IL- 2和 IFN- γ含量 ;组织学检查显示 ,肿瘤细胞大部分变性坏死 ,肿瘤周围有大量淋巴细胞、浆细胞浸润。 结论 :1号生物蜂王浆具有明显抗肿瘤作用 ,其机制可能与抑制或杀伤肿瘤细胞 ,提高机体的免疫功能有关。Objective: To observe the inhibitory effects of biotic royal jelly on the ascitic hepatoma cell H 22 . Methods: Mice bearing H 22 tumor were fed on different types of royal jelly: No.1, 2 and 3. Their anti tumor effects were observed in vivo . The general royal jelly and normal saline were observed as control. Results: Among these biotic royal jelly, the biotic royal jelly No.1 showed obvious tumor inhibiting and survival prolonging effects. In addition, it increased the number of WBC and augmented the amount of IL 2 and IFN γ; the pathological study also indicated the denaturing and necrosis of most tumor cells with nuclei constraining and cell membrane rupturing, and large amount of lymphocytes and plasmacytes infiltrating around the mass. Conclusion: The No.1 biotic royal jelly has obvious anti tumor effect, and it may take effects by inhibiting or killing tumor cells and improving the immunity of the host. [

关 键 词：生物蜂王浆 腹水型肝肿瘤 药物治疗 H22癌细胞 

分 类 号：R735.7[医药卫生—肿瘤]