喉癌细胞DNA倍体和超微结构研究  

A study of DNA ploid and ultrastructure in laryngeal cancer

作　　者：胡俊兰[1] 赵瑞力[1] 周维安[1] 

机构地区：[1]石家在河北医学院附属第四医院头预外科

出　　处：《耳鼻咽喉（头颈外科）》1995年第1期43-46,共4页Chinese Arch Otolaryngology-Head Neck Surg

摘　　要：本文对４８例喉癌际本进行了流式细胞术（ｆｌｏｗｃｙｔｏｍｅｔｒｙ，ＦＣＭ）ＤＮＡ含量观察并对２２例标本进行了超微结构研究，探讨了其与预后的关系。结果显示，本组喉癌ＤＮＡ指数范围在１．０～２．０８，异倍体率为７７．１％（３７／４８例），二倍体肿瘤分化好，全部为ＢｒｏｄｅｒⅠ级或Ⅱ级，异倍体肿瘤大多为Ⅱ级或Ⅲ级。在电镜下，二倍体肿瘤和异倍体肿瘤细胞亦有不同超微结构改变。二倍体和近二倍体肿瘤的预后好，生存期长，异倍体肿瘤的预后差，生存期短。认为应用ＦＣＭ分析癌细胞核的ＤＮＡ含量，对癌的诊断及预后提供了重要的信息。Abstract This paper investigated the flow cytometric DNA contert and ultrastructure in forty-eight cases of carcinoma of larynx and inquired into the relation to prognosis.The results showed that DNA index of laryngeal cancer ranged from 1.0 to 2.08.The aneuploid rate was 77.1%。The diploid tumors were well-differentiated and all of them belonged to Broder’s Ⅰor Ⅱ grade,but most of the aneuDloid tumors distributed to Ⅱ or Ⅲ grade. Their ultrastructures were different.A good prognosis would be obtained in the diploid tumors and the aneuploid tumors had a poor prognosis,In conclusion,the laryngeal cancer DNA content by flow cytometry would offer impor-ant informations for clinical diagnosis and prognosis.

关 键 词：喉肿瘤 鳞状细胞癌 脱氧核糖核酸 DNA 流动血细胞计数 超微结构 电子显微镜检查 

分 类 号：R739.65[医药卫生—肿瘤]