喉癌组织中5α-还原酶和17β-羟类固醇脱氢酶的活性  

Activities of 5α-reductase and 17β-hydroxysteroid dehydrogenase in laryngeal carcinoma

作　　者：王明运[1] 于雪艳[1] 徐松德[1] 胡晓燕[1] 吴湘云 

机构地区：[1]山东医科大学卫生部耳鼻喉重点实验室

出　　处：《中国病理生理杂志》1998年第3期274-277,共4页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金

摘　　要：目的：了解性激素对喉癌的影响。方法：测定２０例喉癌和非喉癌组织的５α－还原酶（５αＲ）和１７β－羟类固醇脱氢酶（１７β－（ＯＨ）ＳＤＨ）的活性，此两酶分别涉及睾酮转化为二氢睾酮和雌二醇转化为雌酮。结果：５αＲ的活性在两种组织中没有差别。相反，１７β－（ＯＨ）ＳＤＨ活性在喉癌组织中明显降低，仅为非喉癌组织的５０％。AIM:To study the effect of sex hormones on laryngeal carcinoma.METHODS:The activities of 5α-reductase(5α-R)and 17β-hydroxysteroid dehydrogenase(17β (OH)SDH) were assied in 20 specimens of carcinous and non-carcinous laryngeal tissues. The two enzymes play an important role in conversion of testosterone into dihydrotestosterone and estrodiol into estrone respectively. RESULTS:The activity of 5α-R is on difference between carcinous tissue and non-carcinous tissue. While the 17β (OH)SDH activity decreased markedly in carcinous tissue. which was only 50% of that in non-carcinous tissue. CONCLUSION:The sex hormones promoted laryngeal carcinoma growth are probably estrogen, not androgen.

关 键 词：喉肿瘤 17β-羟类固醇脱氢酶 雄激素类 雌激素类 5Α-还原酶 

分 类 号：R739.65[医药卫生—肿瘤]