单纯疱疹病毒Ⅰ型潜伏感染的研究——兔三叉神经节致敏T淋巴细胞检测研究  

Studies on Latent Infection of Herpes Simplex Virus Type 1: Investigation on T Lymphocytes in the Trigeminal Ganglia of Rabbits

作　　者：任宏伟[1] 谢立信[1] 董晓光[1] 

机构地区：[1]山东省医学科学院眼科研究所

出　　处：《眼科研究》1991年第4期216-218,共3页Chinese Ophthalmic Research

摘　　要：报告应用抗兔致敏T淋巴细胞的单克隆抗体和ABC免疫组织化学技术对22只实验性单纯疱疹病毒性角膜炎的家兔三叉神经节致敏T淋巴细胞检测的结果。首次揭示在角膜原发感染HSV-Ⅰ过程中三叉神经节内致敏T淋巴细胞的出现。致敏T淋巴细胞在角膜接种后第13天出现,第85天消失。结果表明:T淋巴细胞在TG内HSV-Ⅰ潜伏感染的建立过程中起重要作用。本研究对指导临床治疗提供了理论依据。This paper reports that the trigeminal ganglia of 22 rabbits undergoing primary herpes simplex keratitis were stained for sensitized T lymphocytes with monoclonal antibody specific for rabbit sensitized T lymphocytes and ABC immunohistochemical techniques. The results of this investigation reveal,for the first time, the presence of sensitized T lymphocytes in the trigeminal ganglia of rabbits after primary corneal infection with herpes simplex virus type 1. Infiltration of T cells into the trigeminal ganglia was evident at 13 days after primary ocular infection but these cells had gone at 85 days after infection This investigation demonstrates that the T lymphocyte plays an important role in the establishment of HSV-1 latency in trigeminal ganglia. This investigation provides theoretical evidence for clinical therapy.

关 键 词：三叉神经节 单纯疱疹病毒I型 潜伏感染 T淋巴细胞 角膜炎 单克隆抗体 

分 类 号：R772.21[医药卫生—眼科]