肺癌患者血中维生素A和T细胞亚群的相关性分析  

The Plasma Vitamin A and Subsets of T Lymphocyte in Lung Cancer Patients

作　　者：赵玉霞[1] 李艳杰[1] 闫雪[1] 康健[1] 于润江[1] 

机构地区：[1]中国医科大学呼吸疾病研究所,沈阳110001

出　　处：《中国医科大学学报》2001年第2期133-134,共2页Journal of China Medical University

摘　　要：目的 :了解肺癌患者体内维生素A (V A)的水平和细胞免疫状态 ,探讨V A与T细胞亚群的相关性。方法 :高效液相色谱法检测血清中V A ,间接免疫荧光法检测T细胞亚群。结果 :肺癌组V A为 (0 .40 6± 0 .111)mg/L ;健康对照组为 (0 .5 48± 0 .149)mg/L。两者有显著差别 (P <0 .0 0 1)。T细胞亚群CD3、CD4 、CD4 /CD8明显低于健康对照组 ,CD8高于健康对照组。V A与CD3、CD4 正相关 ,与CD8呈负相关。结论 :肺癌患者体内有V A的缺乏和细胞免疫功能的低下 ,V A与T细胞亚群有明显的相关性。本文提供用V A综合治疗肺癌的临床依据。Objective: Our aims were to evaluate the plasma vitamin A status and the function of T cell dependent immunity in lung cancer patients, so as to explore the correlation between them. Methods:We measured the plasma vitamin A status with HPLC and checked the subsets of T lymphocyte with indirect immunofluorescence technique. Results: The levels of plasma vitamin A in lung cancer patients and in controls were(0.406±0.111)mg/L and(0.548±0.149)mg/L respectively . There was a significant difference between them(P<0.001) . The levels of CD 3, CD 4,and CD 4/CD 8 were lower in lung cancer patients than those in controls, while the level of CD 8 was higher. The plasma vitamin A had positive correlation with CD 3 , CD 4,and negative with CD 8. Conclusion: There is defect of the plasma vitamin A and low level of the function of T cell dependent immunity in lung cancer patients,which shows the obvious correlation between them. This research supplies the basis of clinical therapy to lung cancer with vitamin A.

关 键 词：肺癌 维生素A T细胞亚群 相关性分析 

分 类 号：R734.2[医药卫生—肿瘤]