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出 处:《药学进展》2001年第2期96-99,共4页Progress in Pharmaceutical Sciences
摘 要:Caco 2模型作为药物离体口服特性筛选模型 ,已广泛用于药物在小肠处的各种转运机制研究。该模型来源于人体结肠癌细胞 ,含有多种代谢酶 ,接近体内吸收的实际情况 ,可区分不同药物吸收时摄取和跨膜转运过程。本文对Caco 2模型的建立及其近年来在肽类及肽类类似物吸收特性研究方面的应用作一综述。Caco-2 model, the in vitro model for drug absorption, has been widely used to investigate various intestinal transport processes. Caco-2 cell line from human colon adenocarcinnoma, by which the uptake and transepithelia transport of drugs were able to be determined, contained many drug-metabolizing enzymes and made the model similar to the small intestine. In this article, Caco-2 model and its application in recent research on transport mechanism of peptides and peptidomimetics across epithelia were reviewed.
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