四磺酸卟啉镁对小鼠Lewis肺癌的放射增敏效应  

The radiosensitizing effect 4 - porphyrin magnesium sulfonate for Lewis Lung cancer in mice

作　　者：李光[1] 任青[1] 张银娟[1] 赵晶[1] 高汝贵[1] 

机构地区：[1]中国医科大学第一临床学院

出　　处：《中华放射肿瘤学杂志》1997年第1期46-48,共3页Chinese Journal of Radiation Oncology

摘　　要：探讨四磺酸卟啉镁的放射增敏效应。材料与方法将荷Ｌｅｗｉｓ肺癌的Ｃ５７ＢＬ／６小鼠随机分为４组：对照组、单药组、单放组及用药加放射组。其中单药组和用药加放射组小鼠腹腔单次注射四磺酸卟啉镁１３．７５ｍｇ／ｋｇ体重，单放组和用药加放射组各分１０、１５、２０Ｇｙ３个剂量小组进行单次放射，每组各８只鼠，结果（１）当肿瘤体积达原照射体积４倍时，测得四磺酸卟啉镁的增敏比为１．４５～１．７０，平均１．５８。（２）各组小鼠生存时间无显著差异。结论四磺酸卟啉镁对Ｌｅｗｉｓ肺癌具有放射增敏效应。Purpose To determine the radiosensitizing effect of 4 - porphyrin magnesium sulfonate . Materials and Methods Dividing the C57 BL/6 mice implanted with Lewis lung cancer into four groups in randomization : control group . drug group, radiation group and drug plus radiation group . Among drug group and drug plus radiation group, the intraperitoneal injection of 4 - porphyrin magnesium sulfonate was given according to a dosage of 13. 75 mg per unit weight(kg) of mice , a single radiation was given for radiation group and drug plus radiation group in three dose groups of 10 , 15 , and 20Gy, respectively. Each group included eight mice , Results ( 1 ) when the tumour volume reached to the four times the size of that at the beginning of radiation. the measured SER was 1 . 45 - 1 . 70 , the mean value was 1 , 58 . ( 2 ) No clear difference in the living time was observed among mice in different groups . Conclusion the 4 - porphyrin magnesium sulfonate has radiosensitizing effect for Lewis lung cancer .

关 键 词：西磺酸卟啉镁 放射增敏 Lewis小鼠 肺癌 

分 类 号：R734.2[医药卫生—肿瘤] R730.55[医药卫生—临床医学]