口服避孕药及妊娠情况与女性脑出血的关系  

Correlations between cerebral hemorrhage in women and oral contraceptives and pregnant status

作　　者：徐卫历[1] 汪培山[1] 

机构地区：[1]天津医科大学流行病学教研室,300070

出　　处：《天津医科大学学报》2001年第1期54-55,共2页Journal of Tianjin Medical University

摘　　要：目的 :探讨口服避孕药及妊娠情况与脑出血的关系。方法 :采用配比病例对照研究方法 ,对145例经颅脑CT确诊的女性脑出血病例均配以医院对照 ,应用条件Logistic回归分析。结果 :口服避孕药对女性脑出血的OR为 :2.50(95%CI :1.49～8.20) ,按高血压病史调整后为3.56(95 %CI:1.04～17.82)。单因素分析时 ,妊娠高血压史可增加患脑出血的危险性 ,OR为3.15(95%CI :1.75～5.65),按高血压病史调整后其作用失去显著意义。结论 :口服避孕药很可能是女性脑出血的独立的危险因素 ,提示妊娠高血压可能是借助于影响血压间接地增加了患脑出血的危险性。未发现妊娠次数。Objective:To investigate the correlations between cerebral hemorrhage in women and oral contrceptives and pregnant status. Methods:A1:1 pair matched case control study was conducted on145 women with cerebral hemorrhage diagnosed by CT scan of the head and the same number of hospital controls, using conditional logistic regression analysis.Results: Odds ratio(OR) for OC was 3.50(95%CI:1.49～8.20),after adjusting by the history of hypertension the OR was 3.56 (95%CI:1.04～17.82).Single factor analysis revealed history of pregnant hypertension increased the risk of cerebral hemorrhage the OR were 3.15(95%CI:1.75～5.65) ,after adjusting by the history of hypertension the effects of pregnant hypertension became non-significant. Conclusion:Use of OC were independent risk factor of cerebral hemorrhage in women , it was infered history of pregnant hypertension probably increased the risk of cerebral hemorrhage by influencing blood pressure. No correlations between cerebral hemorrhage in women and history of menstruation and child bearing were found.

关 键 词：口服避孕药 妊娠高血压史 女性脑出血 病例对照研究 

分 类 号：R743.34[医药卫生—神经病学与精神病学]