^(153)钐-乙二胺四甲基膦酸治疗多发性骨转移癌骨痛疗效观察  

Clinical observation of multiple bone metastases with^(153) Sm-EDTMP

作　　者：石静滨[1] 樊辉[1] 郝咏梅[1] 

机构地区：[1]大连医科大学附属第二医院肿瘤放疗科,大连116023

出　　处：《中国综合临床》2001年第5期370-371,共2页Clinical Medicine of China

摘　　要：目的探讨 1 5 3钐 -乙二胺四甲基膦酸 (1 5 3Sm-EDTMP)核素治疗多发性骨转移癌的可行性。方法静脉注射1 5 3Sm-EDTMP 32例 ,每疗程剂量 0 .4～ 1.0 mci/kg(1m Ci=37MBq) ,肝静脉一次注入 ,其中 7例接受 2～ 3次治疗。结果骨痛完全缓解 5 3.1% (17/32 ) ,部分缓解 2 5 .0 % (8/32 ) ,轻度缓解 9.4% (3/32 ) ,无效 12 .5 % (4/32 ) ,总有效率为 78.1%。副作用为 WBC和 (或 ) PLT的 度、 度下降 ,占 15 .6 % (5 /32 ) ,6～ 8周内基本恢复至治疗前水平。结论 1 5 3　 Sm-EDTMP治疗骨广泛转移癌 ,止痛效果确切 。Objective To evaluate the feasibility of 153 Sm EDTMP for multiple bone metastasis.Methods 32 patients with multiple bone metastases were treated with 153 Sm EDTMP injected into the veins,0.4～1.0 mci/kg,of which 7 cases received therapy for 2～3 times.Results 53.1%(17/32)was relieved completely,25.0%(8/32)was relieved partially and 9.4%(3/32)was relieved slightly.No effects were found in 12.5%(4/32).The overall effective rate was 78.1%.Side effects that were the decreasing of WBC and PLT were found in 15.6%(5/32),which rose to the preoperative levels within 6～8 weeks.Conclusion Internal radiotherapy with 153 Sm EDTMP is safe and effective in the treatment of multiple bone metastases.

关 键 词：^153钐 乙二胺四甲基膦酸 骨转移癌 骨痛 放射性核素 疗效 治疗 

分 类 号：R738.1[医药卫生—肿瘤] R730.55[医药卫生—临床医学]