精神分裂症患者听觉P50诱发电位的研究  

Study on P50 auditory evoked potentials in patients with schizophrenia

作　　者：王建军[1] 李乐加[1] 

机构地区：[1]南京医科大学附属脑科医院,南京210029

出　　处：《中国神经精神疾病杂志》2001年第3期203-205,共3页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的 探讨精神分裂症患者听觉Ｐ５０诱发电位的特征和意义。方法 比较３３例精神分裂症患者与３５名正常人Ｐ５０对条件－试验听觉刺激反应的差异。结果 精神分裂症组呈现：①条件刺激Ｐ５０波幅为（２．９４±１．７）μＶ，显著低于正常组（３．８５±１．８）μＶ（Ｐ＜０．０５）。②Ｐ５０抑制显著减弱，它包括试验／条件（Ｔ／Ｃ）比率显著增高，达０．８３±０．２和试验刺激Ｐ５０反应（Ｔ－Ｐ５０）波幅升高，呈抑制显著不足。其Ｐ５０抑制减弱与患者病程无关。结论 精神分裂症患者存在感觉门能力不足，与对听觉刺激的神经非同步性反应有关，并造成感觉超载，它有可能成为精神分裂症心理生理学标记之一。Objective To investigate and characterize the meaning of P50 auditory evoked potentials in patients with schizophrenia. Methods Comparison of the response differences to condition-test auditory stimulus between 33 patients with schizophrenia and 35 normal subjects. Results In the schizophrenia group, the result showed 1. The amplitudes of condition P50 response were(2.94±1.7)V . They were significantly lower in the group than the amplitude(3.85±1.8)μV of the normal group( P< 0.05) . 2. The P50 suppression failure. which includes the test/condition rate(up to 0.83 ± 0.2 ) increase significantly( P <0.01)and the amplitudes of test P50 response increse. It showed the inhibition of gating was significantly lacking, and did not correlate with the course of disease. Conclusions There were sensory gating capability lack in patients with schizophrenia. It has a relationship with neuronal desynchronization response to auditory stimulus, and produces sensory overload. P50 suppression fail-ure may possibly become one of the psychophysiological markers of schizophrenia

关 键 词：精神分裂症 P50 听觉诱发电位 感觉门 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]