肝细胞癌NOS3和VEGF表达的临床意义  

Expression of Nitric Oxide Synthase 3 and Vascular Endothelial Growth Factor in Hepatocellular Carcinoma

作　　者：黄开红[1] 黄志清[1] 李海刚[2] 

机构地区：[1]中山医科大学孙逸仙纪念医院内科消化,广东广州510120 [2]中山医科大学孙逸仙纪念医院病理科,广东广州510120

出　　处：《中山医科大学学报》2001年第3期199-201,共3页Academic Journal of Sun Yat-sen University of Medical Sciences

基　　金：广东省科委科研基金 ( 990 10 1)

摘　　要：【目的】研究肝细胞癌组织中一氧化氮合酶 3(NOS3)和血管内皮生长因子 (VEGF)的表达及其临床意义。【方法】通过免疫组化的方法检测 5 1例肝细胞癌组织NOS3和VEGF的表达。【结果】NOS3和VEGF在 5 1例肝细胞癌组织中的阳性率分别为 5 3%和 6 3% ;NOS3在复发组的阳性率明显高于无复发组 (P <0 0 1) ;VEGF在小肝癌组、门静脉癌栓组和 2年内复发组的阳性率分别高于大肝癌组、无门静脉癌栓组和 2年内未复发组 (P <0 0 5 ) ;肝细胞癌组织中NSO3和VEGF的表达呈正相关 (P <0 .0 0 1)。【结论】NOS3。To investigate the expression of nitric oxide synthase 3 (NOS3) and vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC). The expression of NOS3 and VEGF were detected by immunohistochemistry in 51 cases of HCC. The positive of NOS3 and VEGF in HCC were 53% and 63%. The expression rate of NOS3 in the recurrent group was significantly higher than that in the non recurrent group (P<0.01). The expression rates of VEGF in the group with carcinoma embolus of portal vein and the recurrent group were significantly higher than those in the group without carcinoma embolus and non recurrent group (P<0.05). The expression of NOS3 was closely related with the expression of VEGF positively in HCC. [Conclusions] NOS3 and VEGF are related with the biological behavior of HCC closely.

关 键 词：肝肿瘤 病理学 一氧化氮 血管内皮生长因子 肝细胞癌 

分 类 号：R735.7[医药卫生—肿瘤]