^(153)Sm-盐酸平阳霉素的标记及在小鼠体内的分布  

The preparation and preliminary animal experiment of ^(153)Sm-Pingyangmycin

作　　者：张晓东[1] 粟波[2] 李晴暖[1] 李宇国[1] 谈立松[2] 李文新[1] 曹蓉珍[1] 

机构地区：[1]中国科学院上海原子核研究所放药中心,上海201800 [2]上海市肺科医院肺癌研究室,上海200433

出　　处：《核技术》2001年第5期421-424,共4页Nuclear Techniques

基　　金：上海市卫生局基金! (编号 9740 8)资助;国家自然科学基金! (编号 196 710 33)资助;国际原子能机构的部分资助

摘　　要：研究了153Sm标记盐酸平阳霉素的条件以及标记物在荷S - 180肉瘤小鼠体内的分布情况。结果表明 :当pH为 5— 6,盐酸平阳霉素的量为 1mg时 ,加入适量放射源153SmCl3 溶液 ,室温反应30min可得到标记率 >98%的153Sm -盐酸平阳霉素溶液。室温下放置 72h后 ,放化纯度仍高达 97.2 %。向荷S - 180肉瘤小鼠的静脉中注入该标记物 ,分别在 3、6、12、2 4h处死 ,器官的放射性分布数据显示一定的肿瘤摄取和较高的骨摄取 ,最高分别可达 ( 1.615± 0 .2 19) %ID g和 ( 16.142± 3.50 1) %ID g ,瘤 血和骨 血最高可达 4 8和 90 8。Sm-Pingyangmycin has been prepared by the reaction of 153 SmCl 3 and Pingyangmycin. When the labeling condition was 1mg Pingyangmycin, pH 5—6, 30min reaction time, the labelling yield was greater than 98%. The in vitro stability of 153 Sm- Pingyangmycin was good in 72h. The results of the tissue distribution in Sarcomas-180 mice showed that tumor uptake at 3h after injection was (1.615±0.219)%ID/g and femur uptake at 6h was (16.142±3.501)%ID/g. The ratios of tumor/blood and femur/blood at 24h were 48 and 908 respectively. 153 Sm-Pingyangmycin may be used for the treatment of tumor and bone tumor.

关 键 词：盐酸平阳霉素 S-180肉瘤 小鼠 体内分布 钐153标记物 抗癌抗生素 肿瘤 放射性治疗药物 

分 类 号：R730.55[医药卫生—肿瘤]