胰腺癌区域化疗和全身化疗时5-Fu在门、体静脉血中的动态分布及差异  

Dynamic distribution and comparsion of 5-Fu in portal vein and systemic vein in patients with pancreatic cancer receiving regional or systemic chemotherapy

作　　者：李占元[1] 吕斌[1] 吴清[1] 李鲁传[1] 

机构地区：[1]山东大学齐鲁医院普外科,济南250012

出　　处：《中华外科杂志》2001年第4期263-265,共3页Chinese Journal of Surgery

摘　　要：目的　为胰腺癌区域化疗提供临床实验依据。　方法　 15例手术不能切除的胰腺癌患者行转流术后 ,分别经区域动脉或体静脉快速推注 5 Fu 10 0 0mg ,用反相高效液相色谱法测定门、体静脉血中 5 Fu的浓度。　结果　区域化疗组门静脉血中的 5 Fu浓度在 6 0min以内显著高于体静脉血中 5 Fu的浓度 ,也显著高于同期全身化疗组门静脉血中 5 Fu的浓度 ;而体静脉血中的药物浓度略低于同期全身化疗组。　结论　胰腺癌区域化疗可提高胰腺区域的化疗药物浓度 ,而体静脉血中的化疗药物浓度可保持在较低水平 。Objective To study dynamic distribution of 5 Fu in the portal vein and systemic vein of patients with pancreatic cancer after giving administration of intraarterial and intravenousl 5 Fu. Methods 15 patients with inoperable pancreatic cancer were divided into two groups. In the experimental group (9 patients), a catheter was inserted into the gastroduodenal artery or right gastroepiploic artery. A bolus 5 Fu at the dose of 1?000 mg was infused through the catheter. In the control group (6 patients), a bolus 5 Fu at the same dose was infused through the limb vein. Blood samples were obtained from the portal vein and limb vein for up 60 minutes (10, 20, 30, 60 minutes respectively) after the initiation of drug infusion in both groups. The serum fluorouracil concentrations were determined by reversed phase HPLC method. Results In the experiment group, the concentration of 5 Fu in the portal vein was significantly higher than that in the systemic vein (limb vein) at 10, 20 and 30 minutes respectively; but in the control group, the differences were not significant. The concentration of 5 Fu in the portal vein in the experiment group was significantly higher than that in the control group at 10, 20 and 30 minutes respectively, while the concentration of 5 Fu in the systemic vein was similar in both groups at all time points. ConclusionThese results indicate that regional chemotherapy can produce a significant increase in pancreatic area drug exposure and may keep the low concentration of antineoplasm drug in the systemic vein, which will be helpful to the treatment of pancreatic cancer.

关 键 词：胰腺肿瘤 5-氟脲嘧啶 药物治疗 门静脉血 体静脉血 

分 类 号：R735.9[医药卫生—肿瘤]