淋巴结细胞毒性自然杀伤/T细胞淋巴瘤  

Cytotoxic natural killer/T-cell lymphomas of the lymph nodes

作　　者：林涛[1] 刘卫平[1] 李甘地[1] 李俸媛[1] 袁菊[1] 

机构地区：[1]华西医科大学附属第一医院病理科,成都610041

出　　处：《中华病理学杂志》2001年第2期101-104,共4页Chinese Journal of Pathology

基　　金：国家自然科学基金!资助项目 (390 0 72 0 0 1)

摘　　要：目的　探讨淋巴结细胞毒性自然杀伤 (NK/T)细胞淋巴瘤的临床病理学特征。方法　对 5例淋巴结细胞毒性NK/T细胞淋巴瘤作临床病理观察及随访、用LSAB法做免疫表型分析(CD45RO、CD8、CD5 6、CD30、CD2 0、TIA 1)及EBER1/2原位杂交检测。结果　淋巴结细胞毒性NK/T细胞淋巴瘤的病理组织学特点为 :(1)淋巴结结构明显破坏并被瘤细胞所取代 ;(2 )瘤细胞呈多形性 ;(3)多数肿瘤细胞表达淋巴细胞分化抗原。 5例中CD45RO阳性的有 4例 ,其中 3例瘤细胞同时呈CD5 6阳性 ;1例为无标记细胞性 ;所有病例的TIA 1和EBER均为阳性。结论　淋巴结细胞毒性NK/T细胞淋巴瘤有特征性的形态改变和免疫表型 ,提示肿瘤进展及预后不良。Objective To investigate the clinicopathologic features of cytotoxic natural killer (NK)/T cell lymphomas of the lymph nodes. Methods Clinicopathologic observations and follow up on 5 cases of cytotoxic NK/T cell lymphomas of the lymph nodes, immunohistochemical staining for CD45RO,CD8,CD56,CD30,CD20,TIA 1 and in situ hybridization for EBER1/2 were performed. Results (1) The clinicopathologic features of cytotoxic NK T cell lymphomas of the lymph nodes were summarized; (2) The tumor cells were positive for CD45RO in 4 of the 5 cases, in which 3 cases were also positive for CD56. One case was of null cell type. The tumor cells were positive for TIA 1 and EBER1/2 in all 5 cases. Conclusions The clinicopathological features and special immunophenotypes of cytotoxic NK/T cell lymphomas of the lymph nodes were present in all 5 cases. Clinically, this entity tends to be an aggressive process with poor prognosis.

关 键 词：淋巴结肿瘤 LSAB法 免疫表型 病理 细胞毒性自然杀伤/T细胞淋巴瘤 

分 类 号：R733.1[医药卫生—肿瘤]