癌基因c-fos蛋白产物在口腔鳞癌及癌旁粘膜的表达  

Expression of c-fos protein product in oral squamous cell carcinoma(OSCC)and para-OSCC

作　　者：郑明[1] 张伟[1] 刘境华[1] 张泽兵[2] 汤晓飞[2] 

机构地区：[1]吉林大学口腔医院口腔颌面外科,吉林长春130041 [2]吉林大学口腔医院病理科

出　　处：《白求恩医科大学学报》2001年第3期265-267,共3页Journal of Norman Bethune University of Medical Science

摘　　要：目的 :检测癌基因 c- fos在口腔鳞癌、癌旁粘膜的表达 ,探讨其与口腔鳞癌发生和发展的关系。方法 :采用免疫组织化学 S- P法对 31例口腔鳞癌、2 3例癌旁粘膜中 c- fos的表达情况进行了检测 ,并与正常组织对照。结果 :c- fos在正常口腔粘膜不表达 ,在口腔鳞癌及癌旁粘膜表达较强 ,阳性率为54.8%、65.2 % ,两者间无显著性差异 ( P >0 .0 5)。 c- fos的表达水平与癌组织的分化程度有关( P<0 .0 5) ,肿瘤的分化程度越高其表达水平越高。结论 :c- fos的表达水平可作为判定口腔鳞癌分化的指标 ,c- fos可作为口腔粘膜早期癌变和口腔鳞癌的生物学标记物。Objective: To investigate the expression of c fos oncogene protein product in OSCC,para OSCC and it's role in the occurrence and development of OSCC.Methods:We employed immunohistochemical S P method to investigate the expression of c fos in 31 cases of OSCC, 23 cases of para OSCC, and compared them to normal tissues.Results: There was no expression of c fos in normal oral mucosa,but existed significant overexpression of c fos in OSCC and para OSCC.The positive rates in OSCC and in para OSCC were 54.8% and 65.2%, respectively,and no significant difference was found between them( P >0.05). In OSCC,the expression degree of c fos was related to the differentiation ( P <0.05).Conclusion: c fos could be an index to differentiate OSCC.And it could be regarded as the biological marker of oral mucosa`s initial cancer and OSCC. [

关 键 词：C-FOS 免疫组织化学 口腔鳞癌 癌旁粘膜 

分 类 号：R739.85[医药卫生—肿瘤]