口炎涂剂与思密达对化疗后口腔炎护理效果的比较研究  

Comparison of Kouyan Tuji and Smecta on Chemotherapy induced Oral Mucositis:A Perspective Study

作　　者：王小方[1] 傅菊芳[1] 李武平[2] 杨宏宇[1] 白燕妮[1] 李蕊[1] 方惠涛[1] 

机构地区：[1]第四军医大学西京医院血液科 [2]第四军医大学西京医院护理部,陕西西安710032

出　　处：《解放军护理杂志》2001年第3期17-18,共2页Nursing Journal of Chinese People's Liberation Army

基　　金：西京医院首界 (98年度 )护理科研基金资助项目

摘　　要：目的　对比口炎涂剂与思密达对化疗患者口腔炎的效果 ,为临床选择化疗后口腔炎的最佳护理方案提供依据。方法　将 1997年 6月至 1999年 12月接受化疗后并发口腔炎的 2 6 4例急性白血病患者随机分成 2组 ,A组 (12 8例 )局部涂抹思密达 ,B组 (136例 )局部涂抹口炎涂剂 ,观察比较 2种药物护理效果。结果　A,B两组在年龄、治疗状态、化疗药物对粘膜的损害作用、白细胞数、溃疡性质及分度上无显著差异 ,可比性好。经 Wilcoxon等级资料两样本比较 (u =2 .16 3,P <0 .0 5 ) ,B组疗效优于 A组。结论　口炎涂剂效果明显 ,价格低廉 。Objective To compare the clinical effects of Kouyan Tuji (a self prepared unction for oral mucositis) and Smecta in an attempt to choose an optimal nursing program for chemotherapy induced stomatitis. Methods 264 patients with acute leukemia who had chemotherapy induced oral mucositis from June 1997 to December 1999 were randomized into two groups: Group A (128/264) receiving Smecta as control, and Group B (136/264) receiving Kouyan Tuji. Change of oral mucositis in both groups were observed. There was no significant difference between the two groups in age, therapeutic status, injurious effect of the chemotherapy agents on mucosa, WBC count, and classification of ulceration. Results Patients in both groups showed good response to Smecta (84.8%) and Kouyan Tuji (91.9%), though the difference between the two groups was significant, the latter being better than the former (P<0.05).Conclusion Wilcoxon (u= 2.163 , P<0.05) showed that Kouyan Tuji is much better than Smecta. In addition, Kouyan Yuji is more convenient to apply and lower in cost, and therefore it is worth spreading.

关 键 词：急性白血病 化学治疗 口腔炎 护理 口炎涂剂 思密达 

分 类 号：R733.71[医药卫生—肿瘤] R473.78[医药卫生—临床医学]