磷-32玻璃微球组织内照射抑瘤作用的动物实验研究  

Anticancer Effects of Phosphate-32 Glass Microspheres in Experimental Study

作　　者：郑光勇[1] 王大章[1] 孙文豪 李茂良 

机构地区：[1]华西医科大学口腔颌面外科教研室 [2]核工业部第一研究设计院

出　　处：《华西口腔医学杂志》1991年第2期134-137,共4页West China Journal of Stomatology

基　　金：国家自然科学基金3870834课题

摘　　要：以 BALB/C 小鼠 U_(14)宫颈癌和 S_(180)肉瘤实体瘤为实验肿瘤动物模型,观察磷—32玻璃微球(P—32GMS)内照射对肿瘤生长的抑制作用和对荷瘤小鼠寿命的影响。结果:P—32GMS内照射对 U_(14)宫颈癌和S_(180)肉瘤的生长均有明显的抑制作用(P<0.01和P<0.05),同时对 U_(14)荷瘤小鼠的寿命有延长作用(P<0.05)。文中对P—32GMS 内照射抑瘤作用的影响因素进行了讨论。This article presents a new method of internal radiotherapy—The treatment of malig-nant tumors with intraaterial radioactive microspheres(RMS).A Series of rat tumors(U14 and S180)in BALB/C mice were made.The anticancereffeets of P-32GMS was assessed.The result proved that the tumors inhibition rate ofthe treated groups(77% U14 tumors,51% S180 tumor)were much higher than the cont-ral groups(P<0.05)Also the U14 tumorbearing mice with internal radiation of P-32GMShave longer survival time than that had not treated(P<0.05).The effect efactors of anticaneer action of the P-32GMS is discussed in this paper.

关 键 词：磷32 微球 内照射 恶性肿瘤 

分 类 号：R730.55[医药卫生—肿瘤]