芪甲酸衍生物的合成及抑制乙酰胆碱脂酶活性的研究  

THE SYNTHESIS OF STILBENE-4-CARBOXYLIC ACID DERIVATIVES AND THEIR ACTIVTIES OF INHIBITING THE ACETY CHOLINE STERASE

作　　者：李举联[1] 周一冰 胥佩菱[1] 张泽林[1] 

机构地区：[1]华西医科大学药学院,成都610041 [2]华西医科大学药学院合成专业

出　　处：《华西药学杂志》1991年第3期132-136,共5页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金

摘　　要：本文报道了22个芪甲酸类衍生物的合成及抑制乙酰胆碱酯酶的活性,实验证明其中19个化合物具显著的抑制该酶的活性。抗癌活性筛选正在进行中。In this paper, twenty two new stilbene-4-Carboxylic acid derivatives were Synthesized and their activites of inhibiting acety Cholinester ase are determined, 19 Compounds had shown Signifi cant activity of inhibiting acety Cholinesterase. Their activities of antitumor are being evaluated.

关 键 词：芪甲酸衍生物 合成 乙酰胆碱脂酶 

分 类 号：TQ463.25[化学工程—制药化工]