恶性血液病患者的医院感染特点及易患因素分析  

Characteristic and vulnerable factors of nosocomial infection in patients with malignant hematologic disease

作　　者：傅丽娟 殷素珍 王萍 

机构地区：[1]浙江省湖州市第一医院血液科 313000 [2]浙江省湖州市第一医院检验科 313000

出　　处：《浙江临床医学》2001年第5期317-318,共2页Zhejiang Clinical Medical Journal

摘　　要：目的 了解恶性血液病患者发生医院感染的特点和易患因素。方法 对208例恶性血液病患者医院感染情况 ,进行回顾性分析。结果 208例病人发生102例感染。多部位感染17例。感染导致死亡18例。感染部位以呼吸道口腔粘膜最多见。感染病原菌主要为G-菌和真菌。大剂量化疗、白细胞减少、广谱抗菌素使用、住院时间延长 ,是医院感染的易患因素。 结论 恶性血液病患者 ,应加强监护。白细胞<2.0×109/L者 ,注意保护性隔离。Objective To explore the characteristic and vulnerable factors of nosocomial infection in patients with malignant hematologic disease. Methods The clinical data of 208 patients with malignant hematologic disease were studied retrospectively. Results Nosocomial infection occurred in 102 patients, with 17 cases of multiple sites infection. 18 patients died of infection. Infection often located on oral mucosa and respiratory tract mucosa. Gram negative bacteria and fungi were the common pathogens. Chemotherapy, leucocytopenia , usage of broad-specrtum antibiotic, long hospitalization were the vulnerable factors of nosocomial infection. Conclusion Patients with malignant hematologic disease should be monitored closely, and those with leucocytes less than 2×109 be isolated protectively. Rational application of antibiotics should be emphasized.

关 键 词：恶性血液病 医院感染 易患因素 抗生素 合理用药 

分 类 号：R733[医药卫生—肿瘤] R181.34[医药卫生—临床医学]