电刺激腹中隔区对IL-1_β作用下兔POAH温敏神经元放电特性的影响  

Effects of electrical stimulation of VSA on the firing characteristics of pyrogen-treated thermosensitive neurons in rabbits POAH

作　　者：董军[1] 付咏梅[1] 陆大祥[1] 王华东[1] 柏志全[2] 孙葳[1] 陈小琳[1] 王彦平[1] 张荣华[3] 李楚杰[1] 

机构地区：[1]暨南大学医学院病理生理教研室 [2]暨南大学医学院生理教研室,广东广州510632 [3]暨南大学医学院中医系,广东广州510632

出　　处：《暨南大学学报（自然科学与医学版）》2001年第2期9-13,共5页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：国家自然科学基金!资助项目 (396 0 0 0 6 1) ;国务院侨办科学基金!资助项目 (93- 95 - 8)

摘　　要：目的 :进一步探讨中枢解热机理。方法 :采用微电极细胞外记录 ,观察在致热原IL - 1β作用下电刺激兔腹中隔区 (VSA)对视前区 -下丘脑前部 (POAH)温度敏感神经元放电特性的影响。结果 :(1)IL - 1β 使热敏神经元放电频率减少时 ,电刺激腹中隔区可明显降低POAH热敏神经元的温度敏感系数。 (2 )IL - 1β 使冷敏神经元放电频率增加时 ,电刺激腹中隔区可增加POAH冷敏神经元的温度敏感系数。结论Aim:To clarify further into the antipyretic mechamnism in region. Methods: The firing rate and thermosensitive coefficient of thermosensitive neurons in POAH was observed with extracellular microelectrode technique on 32 New Zealand White rabbits. Results: (1)when intraceretroventriculary(icv) injection of interleukin-1 β(IL-1 β) caused decrease of discharging rate of warm- sensitive neurons in preoptic anterior hypothalamus(POAH), electrical stimulation of ventral septal area(VSA) can remarkablely decrease thermosensitive coefficient of warm-sensitive neurons. (2) when intraceretroventricularly(icv) injection of interleukin-1 β(IL-1 β) caused increase of discharging rate of cold-sensitive neurons in POAH, electrical stiumlation of VSA can remarkabely increase thermosensitive coefficient of cold-sensitive neurons. Conclusion:VSA of negative regulation may antipyretic fever through affecting the firing characteristics of pyrogen-treated thermosensitive neurons in the POAH.

关 键 词：腹中隔区 视前区-下丘脑前部 温敏神经元 单位放电 体温调节 电刺激 解热 发热 

分 类 号：R364.6[医药卫生—病理学]