细胞分化诱导剂与端粒酶活性调控  

Effects of inducers of differentiation on telomerase activity in malignant cells

作　　者：张黎明[1] 贺茜[2] 陈志龙[1] 杨光[3] 

机构地区：[1]第二军医大学海医系防化医学教研室,上海200433 [2]第二军医大学附属长海医院妇产科,上海200433 [3]中国药科大学生物制药专业,本科实习生南京210009

出　　处：《中国药理学通报》2001年第2期140-142,共3页Chinese Pharmacological Bulletin

摘　　要：端粒酶与恶性肿瘤的发生、发展关系密切，是肿瘤治疗的一个新的靶点，细胞分化诱导剂抑制端粒酶活性的研究进展明显。本文介绍了维甲类化合物、维生素Ｄ３类化合物。茶多酚以及苦参碱等多种细胞分化诱导剂对端粒酶活性的影响。More than 85% of all cancers express telomerase activity. Human telomerase has been proposed as a novel and potentially highly selective target for canon therapy. Inducers of differentiation are involved in regulation of telomerase activity. In the present review, the effects of retinoids, vitamin D3 compounds, tea catechins and matrine on telomerase activity in malignant cells were reviewed.

关 键 词：端粒酶 细胞分化诱导剂 维甲类化合物 肿瘤 维生素D3类化合物 

分 类 号：R73[医药卫生—肿瘤] R979.1[医药卫生—临床医学]